peptide chemical synthesis

Synthetic proteins are expected to go beyond the boundary of recombinant DNA expression systems by being flexibly installed with… Expand

Cysteine-based native chemical ligation (NCL) has been a very powerful approach for convergent synthesis of peptides and proteins… Expand

By facilitating formation of the acyl-enzyme intermediate, peptide thioesters can largely promote subtiligase-catalyzed ligation… Expand

Cysteine-mediated native chemical ligation is a powerful method for protein chemical synthesis. Herein, we report an… Expand

Fully unprotected peptide o-aminoanilides can be efficiently activated by NaNO2 in aqueous solution to furnish peptide thioesters… Expand

Successive peptide ligation using a one-pot method can improve the efficiency of protein chemical synthesis. Although one-pot… Expand

An efficient thiol-assisted one-pot synthesis of peptide/protein C-terminal thioacids was achieved by using peptide/protein… Expand

Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as… Expand

The chemical synthesis of proteins provides synthetic chemists with an interesting challenge and supports biological research… Expand

Protein chemical synthesis by native peptide ligation of unprotected peptide segments is an interesting complement and potential… Expand