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peloruside A

National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Laulimalide and peloruside A are microtubule-stabilizing agents (MSAs), the mechanism of action on microtubules of which is… Expand
2010
2010
The stereoselective synthesis of the monocyclic peloruside A analogue 4 has been achieved, following a new efficient approach for… Expand
Highly Cited
2008
Highly Cited
2008
Microtubules are significant therapeutic targets for the treatment of cancer, where suppression of microtubule dynamicity by… Expand
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Highly Cited
2007
Highly Cited
2007
The microtubule stabilizing agent peloruside A binds to a unique site on the tubulin alpha,beta-heterodimer compared to taxoid… Expand
Highly Cited
2006
Highly Cited
2006
Previous studies on the drug content of pelleted tubulin polymers suggest that peloruside A binds in the laulimalide site, which… Expand
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2005
2005
Peloruside A (peloruside), a compound isolated from the marine sponge Mycale hentscheli, inhibits growth of human (HL-60) and… Expand
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Highly Cited
2004
Highly Cited
2004
Peloruside A (peloruside), a microtubule-stabilizing agent from a marine sponge, is less susceptible than paclitaxel to multidrug… Expand
2003
2003
[reaction: see text] The asymmetric synthesis of building blocks 3, 4, and 5, corresponding to C(12)-C(19), C(7)-C(11), and C(1… Expand
Highly Cited
2002
Highly Cited
2002
Peloruside A is a novel secondary metabolite isolated from a New Zealand marine sponge, Mycale hentscheli, that has potent… Expand
Highly Cited
2000
Highly Cited
2000
A novel, polyoxygenated, pyranose ring containing 16-membered macrolide peloruside A (1) exhibiting cytotoxic activity in the… Expand