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pegorgotein

 
National Institutes of Health

Papers overview

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Review
2013
Review
2013
Pharmacological perioperative brain neuroprotection: a qualitative review of randomized clinical trials.
Perioperative cerebral damage may be associated with surgery and anaesthesia. Pharmacological perioperative neuroprotection is… Expand
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Review
2012
Review
2012
A Review of Neuroprotection Pharmacology and Therapies in Patients with Acute Traumatic Brain Injury
Traumatic brain injury (TBI) affects 1.6 million Americans annually. The injury severity impacts the overall outcome and… Expand
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1999
1999
A randomized, blinded trial of the antioxidant pegorgotein: no reduction in neuropsychological deficits, inotropic drug support, or myocardial ischemia after coronary artery bypass surgery.
OBJECTIVE To determine whether patients receiving pegorgotein preoperatively would be less likely than patients receiving placebo… Expand
1997
1997
The use of pegorgotein in the treatment of frostbite.
Free oxygen radicals have been postulated to be an important mediator of injury in frostbite. A long-acting version of the… Expand
Highly Cited
1996
Highly Cited
1996
Effects of pegorgotein on neurologic outcome of patients with severe head injury. A multicenter, randomized controlled trial.
OBJECTIVE To evaluate outcome of patients with severe closed head injury treated with pegorgotein, a scavenger of oxygen-derived… Expand
Highly Cited
1996
Highly Cited
1996
The effect of postinjury administration of polyethylene glycol-conjugated superoxide dismutase (pegorgotein, Dismutec) or lidocaine on behavioral function following fluid-percussion brain injury in…
Previous studies in our laboratory have shown that polyethylene glycol-conjugated superoxide dismutase (PEG-SOD) or lidocaine… Expand
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Highly Cited
1996
Highly Cited
1996
Stretch-induced injury of cultured neuronal, glial, and endothelial cells. Effect of polyethylene glycol-conjugated superoxide dismutase.
BACKGROUND AND PURPOSE There is abundant evidence that after in vivo traumatic brain injury, oxygen radicals contribute to… Expand
1994
1994
Clinical trials with Dismutec (pegorgotein; polyethylene glycol-conjugated superoxide dismutase; PEG-SOD) in the treatment of severe closed head injury.
  • J. P. Muizelaar
  • Advances in experimental medicine and biology
  • 1994
    • Corpus ID: 21276195
Although the suspicion for a role of oxygen radicals in disease and degeneration was raised a long time ago, the first… Expand
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