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pazinaclone

Known as: (+-)-2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(((1,4-dioxa-8-azaspiro(4.5)dec-8-yl)carbonyl)methyl)-1-isoindolinone, A-77000, (+-)-8-((2-(7-Chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl)acetyl)-1,4-dioxa-8-azaspiro(4.5)decane 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

DN 2327

Broader (3)

IsoindolesNaphthyridinesSpiro Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams
Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the structure of many pharmaceutically active… 
2019
2019
Multicomponent Synthesis of Isoindolinones by RhIII Relay Catalysis: Synthesis of Pagoclone and Pazinaclone from Benzaldehyde.
A practical one-pot isoindolinone synthesis enabled by RhIII catalysis was developed. The advantage of this protocol is that it… 
2018
2018
Diastereoselective auxiliary- and catalyst-controlled intramolecular aza-Michael reaction for the elaboration of enantioenriched 3-substituted isoindolinones. Application to the synthesis of a new…
A new asymmetric organocatalyzed intramolecular aza-Michael reaction by means of both a chiral auxiliary and a catalyst for… 
Review
2005
Review
2005
The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics
Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of… 
2002
2002
A new synthesis of 3-alkyl-1-isoindolinones
1996
1996
Absorption of the anxiolytic pazinaclone in animals as a criterion for species selection for toxicity studies.
In rats, mice, hamsters, and guinea pigs given a 5 mg/kg oral dose of pazinaclone (CAS 103255-66-9), unchanged drug concentration… 
1995
1995
Behavioral and subjective effects of DN‐2327 (pazinaclone) and aiprazolam in normal volunteers
DN-2327 (pazinaclone) is a new non-benzodiazepine compound which has high affinity for benzodiazepine receptors. The acute… 
1995
1995
Enantioselective pharmacokinetics in animals of pazinaclone, a new isoindoline anxiolytic, and its active metabolite
The enantioselective pharmacokinetics of a new anxiolytic, pazinaclone (DN‐2327), and its active metabolite, M‐II, were studied… 
1994
1994
Anxiolytic Potential of Benzodiazepine Receptor Partial Agonists
SummaryAnxiety disorders are common psychiatric problems and the cause of considerable morbidity. Following the demise of the… 
1993
1993
Stereoselective pharmacokinetics of pazinaclone, a new non-benzodiazepine anxiolytic, and its active metabolite in healthy subjects.
1. Serum and urine concentrations of enantiomers of pazinaclone (DN-2327) and an active metabolite MII, were measured after… 
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