parecoxib

Known as: N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamide, N-(((Me-P)-P)S)P, Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)- 
An amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The enzyme cyclooxygenase-2 (COX-2), which catalyzes the production of pro-inflammatory prostaglandins, is induced in the brain… (More)
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2009
2009
BACKGROUND Pain after craniotomy is often under-treated. Opiates carry distinct disadvantages. Non-steroidal anti-inflammatory… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Valdecoxib and its intravenous prodrug parecoxib are reported to increase thromboembolic risk after coronary artery… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Valdecoxib and its intravenous prodrug parecoxib are used to treat postoperative pain but may involve risk after… (More)
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2005
2005
Selective inhibitors of cyclooxygenase (COX)-2 1 depress prostacyclin (PGI2) but not COX-1–derived thromboxane A2. The effects of… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Cyclooxygenase-2 inhibitors inhibit bone repair. HYPOTHESIS Cyclooxygenase inhibitors might also have a negative… (More)
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2004
2004
Non-steroidal antiinflammatory drugs (NSAIDs) are known to induce analgesia mainly via inhibition of cyclooxygenase (COX… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE Inhibition of cyclooxygenase 2 provides analgesia in ambulatory patients. We prospectively evaluated the safety and… (More)
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Highly Cited
2003
Highly Cited
2003
Non-steroidal anti-inflammatory drugs (NSAIDs) specifically inhibit cyclooxygenase (COX) activity and are widely used as anti… (More)
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2003
2003
BACKGROUND Forty-eight ASA I-II patients undergoing total abdominal hysterectomy (TAH) were studied in a double blind, randomized… (More)
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