pantetheinase activity

Known as: pantetheine hydrolase activity, vanin-1, vanin 
Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine. [EC:3.5.1.92, RHEA:13448]
National Institutes of Health

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2014
2014
The diagnosis of primary immune thrombocytopenia (ITP) is clinical and cannot be established by any specific laboratory assay… (More)
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2012
2012
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface… (More)
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2012
2012
The pantetheinase vanin-1 generates cysteamine, which inhibits reduced glutathione (GSH) synthesis. Vanin-1 promotes inflammation… (More)
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Highly Cited
2006
Highly Cited
2006
Although the selective tyrosine kinase inhibitor imatinib is successfully used in the treatment of chronic myeloid leukemia (CML… (More)
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2006
2006
Colitis involves immune cell-mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1… (More)
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2004
2004
Vanin-1 is a membrane-anchored pantetheinase highly expressed in the gut and liver. It hydrolyzes pantetheine to pantothenic acid… (More)
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Highly Cited
2004
Highly Cited
2004
Vanin-1 is an epithelial ectoenzyme with pantetheinase activity and generating the amino-thiol cysteamine through the metabolism… (More)
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2001
2001
The mouse Vanin-1 molecule plays a role in thymic reconstitution following damage by irradiation. We recently demonstrated that… (More)
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2000
2000
The mammalian sex-determining pathway is controlled by the presence or absence of SRY expression in the embryonic gonad… (More)
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1999
1999
Pantetheinase is an amidohydrolase involved in the dissimilative pathway of CoA, allowing the turnover of the pantothenate moiety… (More)
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