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The sigma receptors were first classified as a subtype of opioid receptors but later they were found to be a distinct… Expand EMD 57455 (panamesine) is a new sigma receptor ligand alleged to have antipsychotic effects. Animal studies have demonstrated… Expand Antipsychotic efficacy and side effects of the selective sigma ligand EMD 57445 (panamesine) were investigated in 12 patients (6… Expand It has been hypothesized that some of negative effects exerted by cocaine are mediated via sigma (sigma) receptors. This report… Expand Abstract Rationale: EMD 57445 (panamesine) is a high affinity sigma ligand with the profile of an atypical antipsychotic in… Expand Abstract Panamesine (PAN) is a nearly specific sigma ligand. Recently, we showed that PAN in doses up to 90 mg/day improved… Expand This is a review on the recent results of research on sigma-receptor antagonists. NE-100, a selective sigma1-receptor antagonist… Expand Abstract The sigma (σ) receptor has been proposed as a target of neuroleptic drugs. Preclinical data suggest that panamesine (EMD… Expand