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pan-RAF Kinase Inhibitor TAK-580

Known as: MLN-2480, TAK580, MLN2480 
An orally available inhibitor of A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon administration, pan-RAF kinase… 
National Institutes of Health

Papers overview

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2020
2020
Machine learning is a valuable tool in the development of chemical technologies but its applications into supramolecular… 
2019
2019
Targeted inhibition of RAF and MEK by molecularly targeted agents has been employed as a strategy to block aberrant mitogen… 
2017
2017
Background Activating mutations or structural rearrangements in BRAF are identified in roughly 75% of all pediatric low-grade… 
2015
2015
TPS2609 Background: Signaling hyperactivation secondary to MAPK pathway aberrations are common. RAF kinases play key roles in the… 
2013
2013
2547 Background: MLN2480 is an investigational pan-RAF kinase inhibitor. In vivo, MLN2480 showed antitumor activity in melanoma…