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pan-PIM Kinase Inhibitor NVP-LGB-321

Known as: NVP-LGB-321, PIM Inhibitor NVP-LGB-321, PIM Kinase Inhibitor NVP-LGB-321 
An orally available, small molecule and selective ATP-competitive pan-inhibitor of proviral integration sites for Moloney murine leukemia virus (PIM… 
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Evaluation of prevention of mother-to-child transmission (PMTCT) of HIV in a tertiary health institution in south-eastern Nigeria
Mother-to-child transmission is the highest mode of acquisition of HIV infection in children, with a 1545% risk of an infant… 
2013
2013
Effects of PI3K inhibitor NVP-BKM120 on acquired resistance to gefitinib of human lung adenocarcinoma H1975 cells
The effects of class I PI3K inhibitor NVP-BKM120 on cell proliferation, cell cycle distribution, cellular apoptosis… 
2012
2012
Preclinical Development The Novel Oral Hsp 90 Inhibitor NVP-HSP 990 Exhibits Potent and Broad-spectrum Antitumor Activities In Vitro and In Vivo
A novel oral Hsp90 inhibitor, NVP-HSP990, has been developed and characterized in vitro and in vivo. In vitro, NVP-HSP990… 
Review
2011
Review
2011
THE NOVEL ORAL HSP 90 INHIBITOR NVP-HSP 990 EXHIBITS POTENT AND BROAD-SPECTRUM ANTI-TUMOR ACTIVITIES IN VITRO AND IN VIVO
= 176, Text =4987, Figures= 5, Tables= 2, References= 33 on June 23, 2017. © 2012 American Association for Cancer Research. mct… 
2011
2011
Cancer Therapy : Preclinical Dual Targeting of Phosphoinositide 3-Kinase and Mammalian Target of Rapamycin Using NVP-BEZ 235 as a Novel Therapeutic Approach in Human Ovarian Carcinoma
Purpose: This study evaluates the effect of dual PI3K and mTOR inhibition using NVP-BEZ235 in preclinical models of ovarian… 
2010
2010
Abstract 4499: In vitro and in vivo evaluation of novel Pim kinase inhibitors with potent anticancer activity
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC The Pim serine-threonine kinase family is composed… 
2007
2007
Insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 is active in breast cancer cells and enhances growth inhibition by herceptin through an increase in cell cycle arrest
21077 Background: Targeting ErbB2 with the monoclonal antibody trastuzumab (Herceptin) has shown to be active in breast cancer… 
2006
2006
PHARMACOKINETICS (PK) OF THE NOVEL ORAL PROTEIN KINASE C (PKC) INHIBITOR NVP-AEB071(AEB) IN RATS AND NON-HUMAN PRIMATES (NHP): STUDY OF IMMUNOSUPPRESSIVE (IS) EFFICACY AND DISTRIBUTION TO LYMPHATIC…
2005
2005
Evaluation of LBM 415 ( NVP PDF-713 ) , a Novel Peptide Deformylase Inhibitor , for Treatment of Experimental Mycoplasma pneumoniae Pneumonia
Mycoplasma pneumoniae is a major cause of community-acquired pneumonia. We evaluated the efficacy of LBM415, a novel peptide… 
2001
2001
Bit-error-rate analysis for PIM-CDMA optical wireless communication systems
12 A hybrid pulse interval modulation--code-division multiple- access (PIM-CDMA) is proposed for optical wireless communication…