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pagoclone
Known as:
1H-Isoindol-1-One, 2-(7-Chloro-1,8-Naphthyridin-2-yl)-2,3-Dihydro-3-(5-Methyl-2-Oxohexyl)-, (+)-
, 2-(7-chloro-1.8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Isoindoles
Naphthyridines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Multicomponent Synthesis of Isoindolinones by RhIII Relay Catalysis: Synthesis of Pagoclone and Pazinaclone from Benzaldehyde.
Yan Zhang
,
Hai-Jie Zhu
,
+4 authors
Gangguo Zhu
Organic letters
2019
Corpus ID: 73453101
A practical one-pot isoindolinone synthesis enabled by RhIII catalysis was developed. The advantage of this protocol is that it…
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Review
2019
Review
2019
Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams
Edorta Martínez de Marigorta
,
J. M. D. L. Santos
,
A. M. Ochoa de Retana
,
J. Vicario
,
F. Palacios
Beilstein journal of organic chemistry
2019
Corpus ID: 157065451
Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the structure of many pharmaceutically active…
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2010
2010
Exploratory Randomized Clinical Study of Pagoclone in Persistent Developmental Stuttering: The EXamining Pagoclone for peRsistent dEvelopmental Stuttering Study
G. Maguire
,
D. Franklin
,
+11 authors
G. Riley
Journal of clinical psychopharmacology
2010
Corpus ID: 29633149
Introduction: Stuttering is a speech disorder in which the flow of speech is disrupted by repetitions, prolongation, and blocks…
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2008
2008
[(18)F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of beta-amyloid fibrils.
Ji Hoon Lee
,
S. Byeon
,
+6 authors
Dong J. Kim
Bioorganic & medicinal chemistry letters
2008
Corpus ID: 22894683
2006
2006
Evaluation of the Abuse Potential of Pagoclone, a Partial GABAA Agonist
H. de Wit
,
L. Vicini
,
G. Haig
,
T. Hunt
,
D. Feltner
Journal of clinical psychopharmacology
2006
Corpus ID: 33351598
Abstract: This study assessed the abuse potential of pagoclone, a partial agonist at the &ggr;-aminobutyric acid type A (GABAA…
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Review
2005
Review
2005
The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics
J. Atack
Expert opinion on investigational drugs
2005
Corpus ID: 22793644
Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of…
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2005
2005
A proof-of-concept study using [11C]flumazenil PET to demonstrate that pagoclone is a partial agonist
A. Lingford-Hughes
,
S. Wilson
,
A. Feeney
,
P. Grasby
,
D. Nutt
Psychopharmacology
2005
Corpus ID: 35569523
The GABA-ergic system is central to many anxiety disorders and has therefore received much attention. Benzodiazepines are highly…
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Review
2003
Review
2003
Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site.
J. Atack
Current drug targets. CNS and neurological…
2003
Corpus ID: 6478716
With the exception of obsessive compulsive disorder, benzodiazepines (BZs) remain a major first line treatment for anxiety…
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Review
2003
Review
2003
Pagoclone Indevus.
Alan Bateson
Current opinion in investigational drugs
2003
Corpus ID: 34466303
Pagoclone is a cyclopyrrolone GABAA receptor modulator under development by Indevus for the potential treatment of panic and…
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2001
2001
Crossover trial of pagoclone and placebo in patients with DSM-IV panic disorder
J. Sandford
,
S. Forshall
,
+5 authors
D. Nutt
Journal of psychopharmacology
2001
Corpus ID: 13294772
Pagoclone is a cyclopyrrolone that is believed to act as a partial agonist at the γ-aminobutyric acid (GABA) A/benzodiazepine…
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