Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

pagoclone

Known as: 1H-Isoindol-1-One, 2-(7-Chloro-1,8-Naphthyridin-2-yl)-2,3-Dihydro-3-(5-Methyl-2-Oxohexyl)-, (+)-, 2-(7-chloro-1.8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A practical one-pot isoindolinone synthesis enabled by RhIII catalysis was developed. The advantage of this protocol is that it… Expand
2010
2010
Introduction: Stuttering is a speech disorder in which the flow of speech is disrupted by repetitions, prolongation, and blocks… Expand
2008
2008
In this study a novel series of isoindol-1-one and isoindol-1,3-dione derivatives for beta-amyloid-specific binding agents is… Expand
2008
2008
Pagoclone is a novel cyclopyrrolone that acts as a partial GABAA receptor agonist. Preclinical studies suggest that pagoclone may… Expand
  • table 1
  • table 2
2006
2006
The cyclopyrrolone pagoclone binds with roughly equivalent high affinity (0.7-9.1nM) to the benzodiazepine binding site of human… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
2006
2006
Abstract: This study assessed the abuse potential of pagoclone, a partial agonist at the &ggr;-aminobutyric acid type A (GABAA… Expand
2005
2005
The GABA-ergic system is central to many anxiety disorders and has therefore received much attention. Benzodiazepines are highly… Expand
  • figure 1
Review
2003
Review
2003
  • Alan Bateson
  • Current opinion in investigational drugs
  • 2003
  • Corpus ID: 34466303
Pagoclone is a cyclopyrrolone GABAA receptor modulator under development by Indevus for the potential treatment of panic and… Expand
2001
2001
Pagoclone is a cyclopyrrolone that is believed to act as a partial agonist at the γ-aminobutyric acid (GABA) A/benzodiazepine… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2