pagoclone

INTRODUCTION Stuttering is a speech disorder in which the flow of speech is disrupted by repetitions, prolongation, and blocks of… (More)

There is little doubt regarding the therapeutic possibilities of modulation of GABAA receptor function as exemplified by the… (More)

Pagoclone is a novel cyclopyrrolone that acts as a partial GABA(A) receptor agonist. Preclinical studies suggest that pagoclone… (More)

The cyclopyrrolone pagoclone binds with roughly equivalent high affinity (0.7-9.1nM) to the benzodiazepine binding site of human… (More)

This study assessed the abuse potential of pagoclone, a partial agonist at the gamma-aminobutyric acid type A (GABAA… (More)

The GABA-ergic system is central to many anxiety disorders and has therefore received much attention. Benzodiazepines are highly… (More)

Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of… (More)

Pagoclone is a cyclopyrrolone GABAA receptor modulator under development by Indevus for the potential treatment of panic and… (More)

With the exception of obsessive compulsive disorder, benzodiazepines (BZs) remain a major first line treatment for anxiety… (More)

Pagoclone is a cyclopyrrolone that is believed to act as a partial agonist at the gamma-aminobutyric acid (GABA)-A/benzodiazepine… (More)