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pagoclone

Known as: 1H-Isoindol-1-One, 2-(7-Chloro-1,8-Naphthyridin-2-yl)-2,3-Dihydro-3-(5-Methyl-2-Oxohexyl)-, (+)-, 2-(7-chloro-1.8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one 
National Institutes of Health

Papers overview

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2019
2019
A practical one-pot isoindolinone synthesis enabled by RhIII catalysis was developed. The advantage of this protocol is that it… 
Review
2019
Review
2019
Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the structure of many pharmaceutically active… 
2010
2010
Introduction: Stuttering is a speech disorder in which the flow of speech is disrupted by repetitions, prolongation, and blocks… 
2006
2006
Abstract: This study assessed the abuse potential of pagoclone, a partial agonist at the &ggr;-aminobutyric acid type A (GABAA… 
Review
2005
Review
2005
  • J. Atack
  • Expert opinion on investigational drugs
  • 2005
  • Corpus ID: 22793644
Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of… 
2005
2005
The GABA-ergic system is central to many anxiety disorders and has therefore received much attention. Benzodiazepines are highly… 
Review
2003
Review
2003
  • J. Atack
  • Current drug targets. CNS and neurological…
  • 2003
  • Corpus ID: 6478716
With the exception of obsessive compulsive disorder, benzodiazepines (BZs) remain a major first line treatment for anxiety… 
Review
2003
Review
2003
  • Alan Bateson
  • Current opinion in investigational drugs
  • 2003
  • Corpus ID: 34466303
Pagoclone is a cyclopyrrolone GABAA receptor modulator under development by Indevus for the potential treatment of panic and… 
2001
2001
Pagoclone is a cyclopyrrolone that is believed to act as a partial agonist at the γ-aminobutyric acid (GABA) A/benzodiazepine…