pagoclone

Known as: 1H-Isoindol-1-One, 2-(7-Chloro-1,8-Naphthyridin-2-yl)-2,3-Dihydro-3-(5-Methyl-2-Oxohexyl)-, (+)-, 2-(7-chloro-1.8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one 
 

Topic mentions per year

Topic mentions per year

2001-2010
01220012010

Papers overview

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2010
2010
INTRODUCTION Stuttering is a speech disorder in which the flow of speech is disrupted by repetitions, prolongation, and blocks of… (More)
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2010
2010
There is little doubt regarding the therapeutic possibilities of modulation of GABAA receptor function as exemplified by the… (More)
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2008
2008
Pagoclone is a novel cyclopyrrolone that acts as a partial GABA(A) receptor agonist. Preclinical studies suggest that pagoclone… (More)
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2006
2006
The cyclopyrrolone pagoclone binds with roughly equivalent high affinity (0.7-9.1nM) to the benzodiazepine binding site of human… (More)
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2006
2006
This study assessed the abuse potential of pagoclone, a partial agonist at the gamma-aminobutyric acid type A (GABAA… (More)
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2005
2005
The GABA-ergic system is central to many anxiety disorders and has therefore received much attention. Benzodiazepines are highly… (More)
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Review
2005
Review
2005
Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of… (More)
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Review
2003
Review
2003
Pagoclone is a cyclopyrrolone GABAA receptor modulator under development by Indevus for the potential treatment of panic and… (More)
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Review
2003
Review
2003
With the exception of obsessive compulsive disorder, benzodiazepines (BZs) remain a major first line treatment for anxiety… (More)
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2001
2001
Pagoclone is a cyclopyrrolone that is believed to act as a partial agonist at the gamma-aminobutyric acid (GABA)-A/benzodiazepine… (More)
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