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pagoclone

Known as: 1H-Isoindol-1-One, 2-(7-Chloro-1,8-Naphthyridin-2-yl)-2,3-Dihydro-3-(5-Methyl-2-Oxohexyl)-, (+)-, 2-(7-chloro-1.8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

IsoindolesNaphthyridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Multicomponent Synthesis of Isoindolinones by RhIII Relay Catalysis: Synthesis of Pagoclone and Pazinaclone from Benzaldehyde.
A practical one-pot isoindolinone synthesis enabled by RhIII catalysis was developed. The advantage of this protocol is that it… 
2011
2011
Dérivé 2,3-dihydro-isoindol-1-one et composition le comprenant
La presente invention concerne une composition pharmaceutique pour le traitement, le soulagement ou la prevention de maladies… 
2010
2010
Comments on article by Maguire et al: pagoclone trial: questionable findings for stuttering treatment.
2008
2008
[(18)F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of beta-amyloid fibrils.
2008
2008
Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance
Pagoclone is a novel cyclopyrrolone that acts as a partial GABAA receptor agonist. Preclinical studies suggest that pagoclone may… 
2006
2006
The in vivo properties of pagoclone in rat are most likely mediated by 5′-hydroxy pagoclone
2004
2004
Gateways to clinical trials.
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… 
Review
2003
Review
2003
Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site.
  • J. Atack
  • Current Drug Targets - CNS & Neurological…
  • 2003
  • Corpus ID: 6478716
With the exception of obsessive compulsive disorder, benzodiazepines (BZs) remain a major first line treatment for anxiety… 
Review
2003
Review
2003
Pagoclone Indevus.
Pagoclone is a cyclopyrrolone GABAA receptor modulator under development by Indevus for the potential treatment of panic and… 
2001
2001
Crossover trial of pagoclone and placebo in patients with DSM-IV panic disorder
Pagoclone is a cyclopyrrolone that is believed to act as a partial agonist at the γ-aminobutyric acid (GABA) A/benzodiazepine… 
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