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pagoclone

Known as: 1H-Isoindol-1-One, 2-(7-Chloro-1,8-Naphthyridin-2-yl)-2,3-Dihydro-3-(5-Methyl-2-Oxohexyl)-, (+)-, 2-(7-chloro-1.8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

IsoindolesNaphthyridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Multicomponent Synthesis of Isoindolinones by RhIII Relay Catalysis: Synthesis of Pagoclone and Pazinaclone from Benzaldehyde.
A practical one-pot isoindolinone synthesis enabled by RhIII catalysis was developed. The advantage of this protocol is that it… 
Review
2019
Review
2019
Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams
Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the structure of many pharmaceutically active… 
2010
2010
Exploratory Randomized Clinical Study of Pagoclone in Persistent Developmental Stuttering: The EXamining Pagoclone for peRsistent dEvelopmental Stuttering Study
Introduction: Stuttering is a speech disorder in which the flow of speech is disrupted by repetitions, prolongation, and blocks… 
2008
2008
[(18)F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of beta-amyloid fibrils.
2006
2006
Evaluation of the Abuse Potential of Pagoclone, a Partial GABAA Agonist
Abstract: This study assessed the abuse potential of pagoclone, a partial agonist at the &ggr;-aminobutyric acid type A (GABAA… 
Review
2005
Review
2005
The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics
  • J. Atack
  • Expert opinion on investigational drugs
  • 2005
  • Corpus ID: 22793644
Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of… 
2005
2005
A proof-of-concept study using [11C]flumazenil PET to demonstrate that pagoclone is a partial agonist
The GABA-ergic system is central to many anxiety disorders and has therefore received much attention. Benzodiazepines are highly… 
Review
2003
Review
2003
Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site.
  • J. Atack
  • Current drug targets. CNS and neurological…
  • 2003
  • Corpus ID: 6478716
With the exception of obsessive compulsive disorder, benzodiazepines (BZs) remain a major first line treatment for anxiety… 
Review
2003
Review
2003
Pagoclone Indevus.
  • Alan Bateson
  • Current opinion in investigational drugs
  • 2003
  • Corpus ID: 34466303
Pagoclone is a cyclopyrrolone GABAA receptor modulator under development by Indevus for the potential treatment of panic and… 
2001
2001
Crossover trial of pagoclone and placebo in patients with DSM-IV panic disorder
Pagoclone is a cyclopyrrolone that is believed to act as a partial agonist at the γ-aminobutyric acid (GABA) A/benzodiazepine… 
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