Skip to search formSkip to main contentSkip to account menu

p110beta/delta PI3K Inhibitor GS-9820

Known as: GS-9820 
An inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential… 
National Institutes of Health

Related topics

Related topics

1 relation

Narrower (1)

CAL-120

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Final results of a phase 1b study of the safety and efficacy of the PI3Kδ inhibitor acalisib (GS-9820) in relapsed/refractory lymphoid malignancies
Final results of a phase 1b study of the safety and efficacy of the PI3Kδ inhibitor acalisib (GS-9820) in relapsed/refractory… 
2016
2016
PI3Kɑ inhibition reduces obesity in mice
Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity. The best… 
2016
2016
PI3Kδ Inhibition Elicits Anti-Leukemic Effects through Bim-Dependent Apoptosis
Introduction: Phosphatidylinositol-3-kinase δ (PI3Kδ)-signaling provides key maintenance, proliferation, and survival cues during… 
Review
2015
Review
2015
PI3K inhibitors in inflammation, autoimmunity and cancer
2013
2013
Effects of Isoform-selective Phosphatidylinositol 3-Kinase Inhibitors on Osteoclasts
Background: Little is known about the function of specific phosphatidylinositol 3-kinase (PI3K) isoforms in osteoclasts. Results… 
2013
2013
Interim Analysis Of Dose-Escalation Stage Of a Phase 1b Study Evaluating Safety and Pharmacology Of GS-9820, a Second-Generation, Selective, PI3Kd-Inhibitor in Recurrent Lymphoid Malignancies
Background In B-cells, phosphatidylinositol 3-kinase delta (PI3Kd) mediates a positive effect on cell survival, proliferation… 
2013
2013
Phosphatidylinositol-3-Kinase p110d Uniquely Promotes Gain-Of-Function PTPN11-Induced GM-CSF Hypersensitivity In a Model Of Juvenile Myelomonocytic Leukemia
Juvenile myelomonocytic leukemia (JMML) is a fatal leukemia affecting children under the age of 4 years and is characterized by… 
2012
2012
Phosphoinositide 3'-Kinase (PI3K) Delta Inhibitor, GS-9820, Enhances Anti-Tumor Efficacy When Combined with Conventional Chemotherapeutic Agents in Primary Samples and Human Tumor Xenograft Model of…
Abstract 4017 Phosphatidylinositide 3-kinases (PI3K) are a family of lipid kinases that are involved in signaling events which… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License