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p-cyanophenylalanine

 
National Institutes of Health

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3 relations

Broader (2)

AlanineNitriles
analogs & derivatives

Papers overview

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2016
2016
Selenomethionine, p-cyanophenylalanine pairs provide a convenient, sensitive, non-perturbing fluorescent probe of local helical structure.
The use of selenomethionine (MSe)-p-cyanophenylalanine (FCN) pairs to probe protein structure is demonstrated. MSe quenches FCN… Expand
2015
2015
p-Cyanophenylalanine and selenomethionine constitute a useful fluorophore-quencher pair for short distance measurements: application to polyproline peptides.
The C≡N stretching frequency and fluorescence quantum yield of p-cyanophenylalanine are sensitive to environment. As such, this… Expand
2015
2015
Measurement of the membrane dipole electric field in DMPC vesicles using vibrational shifts of p-cyanophenylalanine and molecular dynamics simulations.
The magnitude of the membrane dipole field was measured using vibrational Stark effect (VSE) shifts of nitrile oscillators placed… Expand
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2015
2015
New aspects of the structure and mode of action of the human cathelicidin LL-37 revealed by the intrinsic probe p-cyanophenylalanine.
The human cathelicidin peptide LL-37 is an important effector of our innate immune system and contributes to host defence with… Expand
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Highly Cited
2013
Highly Cited
2013
Labeling proteins with fluorophore/thioamide Förster resonant energy transfer pairs by combining unnatural amino acid mutagenesis and native chemical ligation.
We have recently shown that p-cyanophenylalanine (Cnf) and a thioamide can be used as a minimally perturbing Förster resonant… Expand
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Highly Cited
2012
Highly Cited
2012
Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20.
Islet amyloid polypeptide (IAPP, amylin) is responsible for amyloid formation in type 2 diabetes and in islet cell transplants… Expand
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Highly Cited
2010
Highly Cited
2010
Thioamides as fluorescence quenching probes: minimalist chromophores to monitor protein dynamics.
Decreasing the size of spectroscopic probes can afford higher-resolution structural information from fluorescence experiments… Expand
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Highly Cited
2010
Highly Cited
2010
Nitrile bonds as infrared probes of electrostatics in ribonuclease S.
Three different nitrile-containing amino acids, p-cyanophenylalanine, m-cyanophenylalanine, and S-cyanohomocysteine, have been… Expand
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Highly Cited
2009
Highly Cited
2009
Interpretation of p-cyanophenylalanine fluorescence in proteins in terms of solvent exposure and contribution of side-chain quenchers: a combined fluorescence, IR and molecular dynamics study.
The use of noncoded amino acids as spectroscopic probes of protein folding and function is growing rapidly, in large part because… Expand
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2008
2008
The Fluorescent Amino Acid p‐Cyanophenylalanine Provides an Intrinsic Probe of Amyloid Formation
Amyloid formation has been implicated in more than fifteen different human diseases including Alzheimer’s disease, Parkinson’s… Expand
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