oxidative demethylation

The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1948-2017
051019482016

Papers overview

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2015
2015
Growth arrest and DNA-damage-inducible protein 45 (Gadd45) family members have been implicated in DNA demethylation in… (More)
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Highly Cited
2014
Highly Cited
2014
Tet-mediated DNA oxidation is a recently identified mammalian epigenetic modification, and its functional role in cell-fate… (More)
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2010
2010
Mononuclear iron-containing oxygenases conduct a diverse variety of oxidation functions in biology, including the oxidative… (More)
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Highly Cited
2008
Highly Cited
2008
The human obesity susceptibility gene, FTO, encodes a protein that is homologous to the DNA repair AlkB protein. The AlkB family… (More)
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2008
2008
Bacterial and mammalian AlkB proteins are iron(II)- and 2-oxoglutarate-dependent dioxygenases that reverse methylation damage… (More)
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2006
2006
Methylating agents are ubiquitous in the environment, and central in cancer therapy. The 1-methyladenine and 3-methylcytosine… (More)
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Highly Cited
2002
Highly Cited
2002
The bacterial AlkB protein is known to be involved in cellular recovery from alkylation damage; however, the function of this… (More)
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Highly Cited
1991
Highly Cited
1991
The antiestrogen tamoxifen (Tam or Nolvadex, ICI)-Z-1-[4-[2-(dimethylamino) ethoxy]phenyl]-1,2-diphenyl-1-butene is widely used… (More)
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1967
1967
The effect of administration of carbon tetrachloride and dimethylnitrosamine in vivo on hepatic microsomal function related to… (More)
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1948
1948
Handler, Bernheim, and Klein (1) have shown that the oxidation of the N-methyl derivatives of nL-methionine, m-leucine, nL… (More)
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