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ovalicin

 
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
ABSTRACT Therapies for microsporidiosis in humans are limited, and fumagillin, which appears to be the most broadly effective… Expand
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2005
2005
[reaction: see text] A new synthesis of epoxyketone 22 is described that is a key intermediate in Barton's synthesis of ovalicin… Expand
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2005
2005
A new approach to the bengamides, a new class of antitumor natural products of marine origin, is reported from epoxyamides… Expand
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Highly Cited
2001
Highly Cited
2001
The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis. One of the best-characterized enzymes… Expand
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2001
2001
The biological effects of cyclosporin, namely immunosuppression and absence of cytotoxicity, were discovered-in the course of a… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The angiogenesis inhibitors TNP-470 and ovalicin potently suppress endothelial cell growth. Both drugs also… Expand
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Highly Cited
1998
Highly Cited
1998
Angiogenesis inhibitors are a novel class of promising therapeutic agents for treating cancer and other human diseases… Expand
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1998
1998
TNP-470 (1), a synthetic derivative of the natural product fumagillin (2), potently inhibits angiogenesis in vivo and the growth… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Angiogenesis, the formation of new blood vessels, is essential for tumor growth. The inhibition of angiogenesis is… Expand
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1968
1968
The structure of ovalicin, a metabolite of the fungus Pseudeurotium ovalis with immunosuppressive activity, has been determined… Expand
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