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ovalicin

National Institutes of Health

Papers overview

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Review
2010
Review
2010
This review focuses on the synthetic strategies used for the construction of fumagillin, ovalicin, and other natural products of… Expand
Highly Cited
2006
Highly Cited
2006
ABSTRACT Therapies for microsporidiosis in humans are limited, and fumagillin, which appears to be the most broadly effective… Expand
2005
2005
[reaction: see text] A new synthesis of epoxyketone 22 is described that is a key intermediate in Barton's synthesis of ovalicin… Expand
Highly Cited
2001
Highly Cited
2001
The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis. One of the best-characterized enzymes… Expand
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Highly Cited
2001
Highly Cited
2001
The biological effects of cyclosporin, namely immunosuppression and absence of cytotoxicity, were discovered-in the course of a… Expand
Highly Cited
1999
Highly Cited
1999
BACKGROUND The angiogenesis inhibitors TNP-470 and ovalicin potently suppress endothelial cell growth. Both drugs also… Expand
Highly Cited
1998
Highly Cited
1998
Angiogenesis inhibitors are a novel class of promising therapeutic agents for treating cancer and other human diseases… Expand
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1998
1998
TNP-470 (1), a synthetic derivative of the natural product fumagillin (2), potently inhibits angiogenesis in vivo and the growth… Expand
Highly Cited
1997
Highly Cited
1997
BACKGROUND Angiogenesis, the formation of new blood vessels, is essential for tumor growth. The inhibition of angiogenesis is… Expand
Highly Cited
1968
Highly Cited
1968
The structure of ovalicin, a metabolite of the fungus Pseudeurotium ovalis with immunosuppressive activity, has been determined… Expand