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ovalicin

National Institutes of Health

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Sesquiterpenes

Papers overview

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Review
2010
Review
2010
Syntheses of fumagillin and ovalicin.
This review focuses on the synthetic strategies used for the construction of fumagillin, ovalicin, and other natural products of… Expand
Highly Cited
2006
Highly Cited
2006
Antimicrosporidial Activities of Fumagillin, TNP-470, Ovalicin, and Ovalicin Derivatives In Vitro and In Vivo
ABSTRACT Therapies for microsporidiosis in humans are limited, and fumagillin, which appears to be the most broadly effective… Expand
2005
2005
Synthesis of ovalicin starting from D-mannose.
[reaction: see text] A new synthesis of epoxyketone 22 is described that is a key intermediate in Barton's synthesis of ovalicin… Expand
Highly Cited
2001
Highly Cited
2001
Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation
The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis. One of the best-characterized enzymes… Expand
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Highly Cited
2001
Highly Cited
2001
The controversial early history of cyclosporin.
The biological effects of cyclosporin, namely immunosuppression and absence of cytotoxicity, were discovered-in the course of a… Expand
Highly Cited
1999
Highly Cited
1999
Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells.
BACKGROUND The angiogenesis inhibitors TNP-470 and ovalicin potently suppress endothelial cell growth. Both drugs also… Expand
Highly Cited
1998
Highly Cited
1998
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2.
Angiogenesis inhibitors are a novel class of promising therapeutic agents for treating cancer and other human diseases… Expand
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1998
1998
Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression.
TNP-470 (1), a synthetic derivative of the natural product fumagillin (2), potently inhibits angiogenesis in vivo and the growth… Expand
Highly Cited
1997
Highly Cited
1997
Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.
BACKGROUND Angiogenesis, the formation of new blood vessels, is essential for tumor growth. The inhibition of angiogenesis is… Expand
Highly Cited
1968
Highly Cited
1968
[Isolation and structure elucidation of ovalicin].
The structure of ovalicin, a metabolite of the fungus Pseudeurotium ovalis with immunosuppressive activity, has been determined… Expand
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