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This review focuses on the synthetic strategies used for the construction of fumagillin, ovalicin, and other natural products of… Expand ABSTRACT Therapies for microsporidiosis in humans are limited, and fumagillin, which appears to be the most broadly effective… Expand [reaction: see text] A new synthesis of epoxyketone 22 is described that is a key intermediate in Barton's synthesis of ovalicin… Expand The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis. One of the best-characterized enzymes… Expand The biological effects of cyclosporin, namely immunosuppression and absence of cytotoxicity, were discovered-in the course of a… Expand BACKGROUND
The angiogenesis inhibitors TNP-470 and ovalicin potently suppress endothelial cell growth. Both drugs also… Expand Angiogenesis inhibitors are a novel class of promising therapeutic agents for treating cancer and other human diseases… Expand TNP-470 (1), a synthetic derivative of the natural product fumagillin (2), potently inhibits angiogenesis in vivo and the growth… Expand BACKGROUND
Angiogenesis, the formation of new blood vessels, is essential for tumor growth. The inhibition of angiogenesis is… Expand The structure of ovalicin, a metabolite of the fungus Pseudeurotium ovalis with immunosuppressive activity, has been determined… Expand