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orlistat

Known as: (-)-Tetrahydrolipstatin, Orlipastat, tetrahydrolipastatin 
A reversible active-site inhibitor of gastrointestinal lipases. Orlistat forms a covalent bond with the active serine site in gastric and pancreatic… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
The obesity epidemic is closely associated with the rising prevalence and severity of nonalcoholic fatty liver disease (NAFLD… Expand
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Review
2007
Review
2007
Antiobesity treatment is recommended for selected patients in whom lifestyle modification is unsuccessful. Two antiobesity drugs… Expand
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Highly Cited
2005
Highly Cited
2005
CONTEXT The prevalence of overweight and obesity in children and adolescents is increasing rapidly. In this population… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE It is well established that the risk of developing type 2 diabetes is closely linked to the presence and duration of… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To determine the effect of orlistat, a new lipase inhibitor, on long-term weight loss, to determine the extent to which… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To evaluate the long-term efficacy and tolerability within primary care settings of orlistat, a gastrointestinal lipase… Expand
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Highly Cited
1999
Highly Cited
1999
CONTEXT Orlistat, a gastrointestinal lipase inhibitor that reduces dietary fat absorption by approximately 30%, may promote… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND We undertook a randomised controlled trial to assess the efficacy and tolerance of orlistat, a gastrointestinal lipase… Expand
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Highly Cited
1998
Highly Cited
1998
OBJECTIVE Obesity is an important risk factor for type 2 diabetes. Weight loss in patients with type 2 diabetes is associated… Expand
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Review
1997
Review
1997
  • R. Guerciolini
  • International journal of obesity and related…
  • 1997
  • Corpus ID: 8601296
Gastric and pancreatic lipases are enzymes that play a pivotal role in the digestion of dietary fat. Orlistat, a semisynthetic… Expand
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