orlistat

Known as: (-)-Tetrahydrolipstatin, Orlipastat, tetrahydrolipastatin 
A reversible active-site inhibitor of gastrointestinal lipases. Orlistat forms a covalent bond with the active serine site in gastric and pancreatic… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The aim of this study was to determine if orlistat, an inhibitor of fat absorption, combined with caloric restriction in… (More)
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Review
2007
Review
2007
Antiobesity treatment is recommended for selected patients in whom lifestyle modification is unsuccessful. Two antiobesity drugs… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE It is well established that the risk of developing type 2 diabetes is closely linked to the presence and duration of… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To determine the effect of orlistat, a new lipase inhibitor, on long-term weight loss, to determine the extent to which… (More)
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Review
2000
Review
2000
Orlistat, a weight-loss agent with a novel mechanism of action, recently was approved by the Food and Drug Administration for the… (More)
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Highly Cited
1999
Highly Cited
1999
CONTEXT Orlistat, a gastrointestinal lipase inhibitor that reduces dietary fat absorption by approximately 30%, may promote… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND We undertook a randomised controlled trial to assess the efficacy and tolerance of orlistat, a gastrointestinal lipase… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECTIVE Obesity is an important risk factor for type 2 diabetes. Weight loss in patients with type 2 diabetes is associated… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND We undertook a randomised controlled trial to assess the efficacy and tolerability of orlistat, a gastrointestinal… (More)
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Review
1997
Review
1997
Gastric and pancreatic lipases are enzymes that play a pivotal role in the digestion of dietary fat. Orlistat, a semisynthetic… (More)
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