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organic solute transporter alpha, human

Known as: OSTalpha protein, human 
National Institutes of Health

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Broader (1)

Membrane Transport Proteins

Papers overview

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Highly Cited
2010
Highly Cited
2010
Mouse organic solute transporter α deficiency enhances renal excretion of bile acids and attenuates cholestasis
Organic solute transporter alpha‐beta (Ostα‐Ostβ) is a heteromeric bile acid and sterol transporter that facilitates the… 
Review
2010
Review
2010
Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.
Organic solute transporter alpha-beta (OSTalpha-OSTbeta) is a unique heteromeric transporter localized to the basolateral… 
Highly Cited
2008
Highly Cited
2008
The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis
The apical sodium-dependent bile acid transporter (Asbt) is responsible for transport across the intestinal brush border membrane… 
Highly Cited
2008
Highly Cited
2008
Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver.
Mice deficient in the organic solute transporter (Ost)-alpha subunit of the heteromeric organic solute and steroid transporter… 
Highly Cited
2006
Highly Cited
2006
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.
Organic solute transporter (OSTalpha-OSTbeta) is a novel heteromeric bile acid and sterol transporter expressed at the… 
Highly Cited
2006
Highly Cited
2006
Mrp4−/− mice have an impaired cytoprotective response in obstructive cholestasis
Mrp4 is a member of the multidrug resistance–associated gene family that is expressed on the basolateral membrane of hepatocytes… 
Highly Cited
2006
Highly Cited
2006
Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids.
The mechanisms responsible for bile acid regulation of mouse intestinal organic solute transporter alpha-beta (Ostalpha-Ostbeta… 
Highly Cited
2005
Highly Cited
2005
The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter.
Bile acids are transported across the ileal enterocyte brush border membrane by the well characterized apical sodium-dependent… 
Highly Cited
2005
Highly Cited
2005
OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.
The cellular and subcellular localization and mechanism of transport of the heteromeric organic solute transporter (OST) OSTalpha… 
Highly Cited
2003
Highly Cited
2003
Functional Complementation between a Novel Mammalian Polygenic Transport Complex and an Evolutionarily Ancient Organic Solute Transporter, OSTα-OSTβ*
These studies identify an organic solute transporter (OST) that is generated when two novel gene products are co-expressed… 
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