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omega-Agatoxin IVA

Known as: omega-Aga-IVA, IVA, omega-Agatoxin, omega-Agatoxin IVA [Chemical/Ingredient] 
A neuropeptide toxin from the venom of the funnel web spider, Agelenopsis aperta. It inhibits CALCIUM CHANNELS, P-TYPE by altering the voltage… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
We used a preparation of acutely dissociated neurons to quantify the ionic currents driving the spontaneous firing of substantia… Expand
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Highly Cited
2001
Highly Cited
2001
Despite the role of excitatory transmission to the nucleus accumbens (NAc) in the actions of most drugs of abuse, the presence… Expand
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Highly Cited
2000
Highly Cited
2000
Multiple types of high-voltage-activated Ca2+channels trigger neurotransmitter release at the mammalian central synapse. Among… Expand
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Highly Cited
1997
Highly Cited
1997
Abstract: Amyloid β protein (Aβ), the central constituent of senile plaques in Alzheimer's disease (AD) brain, is known to exert… Expand
Highly Cited
1995
Highly Cited
1995
The manner in which presynaptic Ca2+ influx controls the release of neurotransmitter was investigated at the granule cell to… Expand
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Highly Cited
1993
Highly Cited
1993
N-type calcium channels play a dominant role in controlling synaptic transmission in many peripheral neurons. Transmitter release… Expand
Highly Cited
1993
Highly Cited
1993
The regulation of excitation-secretion coupling by Ca2+ channels is a fundamental property of the nerve terminal. Peptide toxins… Expand
Highly Cited
1992
Highly Cited
1992
The peptide toxin omega-Aga-IVA blocked P-type Ca2+ channel current in rat Purkinje neurons (KD approximately 2 nM) but had no… Expand
Highly Cited
1992
Highly Cited
1992
Presynaptic calcium channels are crucial elements of neuronal excitation-secretion coupling. In mammalian brain, they have been… Expand
Highly Cited
1992
Highly Cited
1992
Voltage-dependent calcium channels mediate calcium entry into neurons, which is crucial for many processes in the brain including… Expand