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omapatrilat

Known as: octahydro-4-((2-mercapto-1-oxo-3-phenylpropyl)amino)-5-oxo-7H-pyrido(2,1-b)(1,3)thiazepine-7-carboxylic acid, Omapatrilate, (4S,7S,10aS)-Octahydro-4-((S)-Alpha-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic Acid 
A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
OBJECTIVES The goal of this study was to investigate the association between natriuretic peptides and body fat distribution in a… Expand
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Review
2008
Review
2008
The obesity pandemic is closely related to hypertension and metabolic syndrome. Visceral adipose tissue plays a key role in the… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Recent reports suggest that existing antihypertensive agents may not have sufficient efficacy to control blood… Expand
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Highly Cited
2002
Highly Cited
2002
Background—Combined inhibition of the angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) may produce greater… Expand
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Highly Cited
2002
Highly Cited
2002
Background—Increased pulse pressure, an indicator of conduit vessel stiffness, is a strong independent predictor of… Expand
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Highly Cited
2002
Highly Cited
2002
  • A. Coats
  • International journal of cardiology
  • 2002
  • Corpus ID: 8336947
At the American College of Cardiology in March two major trials were presented. The publicity surrounding the two could not have… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND We aimed to assess in patients with congestive heart failure whether dual inhibition of neutral endopeptidase and… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVES We sought to examine the effects of long-term vasopeptidase inhibition in patients with heart failure. BACKGROUND… Expand
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Highly Cited
1999
Highly Cited
1999
Vasopeptidase inhibitors are single molecules that inhibit neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE… Expand
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Highly Cited
1998
Highly Cited
1998
Combined inhibition of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) produces cardiovascular effects… Expand
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