omalizumab

Known as: Immunoglobulin G, anti-(human immunoglobulin E Fc region)(human-mouse monoclonal E25 clone pSVIE26 gamma-chain), disulfide with human-mouse monoclonal E25 clone pSVIE26 kappa-chain, dimer, Omalizumab [Chemical/Ingredient], Ig gamma-1 chain C region 
An anti-IgE, recombinant, humanized monoclonal antibody which specifically binds to the C epsilon3 domain of IMMUNOGLOBULIN E, the site of high… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
BACKGROUND Many patients with chronic idiopathic urticaria (also called chronic spontaneous urticaria) do not have a response to… (More)
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Highly Cited
2013
Highly Cited
2013
Monitoring free serum IgE in severe asthma patients treated with omalizumab. 2 Omalizumab is effective in allergic and… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Research has underscored the effects of exposure and sensitization to allergens on the severity of asthma in inner… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Approximately 45% of patients with chronic urticaria have an IgG autoantibody directed to the alpha-subunit of the… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Patients with severe persistent asthma who are inadequately controlled despite Global Initiative for Asthma (GINA… (More)
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Highly Cited
2004
Highly Cited
2004
IgE plays an important role in allergic asthma. We hypothesized that reducing IgE in the airway mucosa would reduce airway… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Dendritic cells (DCs) are potent antigen-presenting cells that express FcepsilonRI, the high-affinity IgE receptor… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND A recombinant humanized anti-IgE mAb, omalizumab, forms complexes with free IgE, blocking its interaction with mast… (More)
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Highly Cited
2001
Highly Cited
2001
The clinical benefit and steroid-sparing effect of treatment with the anti-immunoglobulin-E (IgE) antibody, omalizumab, was… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND AND OBJECTIVE There seems to be a strong causal relationship between allergy and the origins of asthma. Susceptibility… (More)
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