ob/ob Mouse

Known as: ob/ob 
The obese mutant mouse was derived from a spontaneous mutation in a V/Le progenitor mouse at the Jackson Laboratory in 1949.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2017
05010015019652017

Papers overview

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Highly Cited
2006
Highly Cited
2006
Leptin is an adipocyte-derived hormone that acts on the hypothalamus to influence feeding, metabolism and reproduction, but the… (More)
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Highly Cited
2006
Highly Cited
2006
Obesity is a metabolic disorder often associated with type 2 diabetes, insulin resistance, and hepatic steatosis. Leptin… (More)
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Highly Cited
2004
Highly Cited
2004
Diabetes alters cardiac substrate metabolism. The cardiac phenotype in insulin-resistant states has not been comprehensively… (More)
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Highly Cited
2000
Highly Cited
2000
Leptin, the product of the obese gene, is a circulating hormone secreted primarily from adipocytes. The lack of leptin in ob/ob… (More)
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Highly Cited
1999
Highly Cited
1999
Thymic atrophy is a prominent feature of malnutrition. Forty-eight hours' starvation of normal mice reduced the total thymocyte… (More)
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Highly Cited
1996
Highly Cited
1996
Correction of the obese state induced by genetic leptin deficiency reduces elevated levels of both blood glucose and hypothalamic… (More)
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Highly Cited
1996
Highly Cited
1996
Leptin, a hormone secreted by adipocytes, regulates the size of the adipose tissue mass through effects on satiety and energy… (More)
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Highly Cited
1995
Highly Cited
1995
The recent positional cloning of the mouse ob gene and its human homology has provided the basis to investigate the potential… (More)
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Highly Cited
1995
Highly Cited
1995
To determine whether the product of the recently cloned ob gene functions as an adipose-related satiety factor, recombinant… (More)
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Highly Cited
1976
Highly Cited
1976
Reproductive function is impaired in the genetically obese (C57 B1/6J) ob/ob mouse. Serum LH, FSH, and testosterone… (More)
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