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ob/ob Mouse

Known as: ob/ob 
The obese mutant mouse was derived from a spontaneous mutation in a V/Le progenitor mouse at the Jackson Laboratory in 1949.
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Chronic inflammation and reduced adiponectin are widely observed in the white adipose tissue in obesity. However, the cause of… Expand
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Highly Cited
2006
Highly Cited
2006
Leptin is an adipocyte-derived hormone that acts on the hypothalamus to influence feeding, metabolism and reproduction, but the… Expand
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Highly Cited
2005
Highly Cited
2005
We have analyzed 5,088 bacterial 16S rRNA gene sequences from the distal intestinal (cecal) microbiota of genetically obese ob/ob… Expand
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Highly Cited
2004
Highly Cited
2004
Diabetes alters cardiac substrate metabolism. The cardiac phenotype in insulin-resistant states has not been comprehensively… Expand
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Highly Cited
2003
Highly Cited
2003
The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and… Expand
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Highly Cited
2000
Highly Cited
2000
In mice with too little fat (lipodystrophy) or too much fat (ob/ob), leptin deficiency leads to hyperglycemia, hyperinsulinemia… Expand
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Highly Cited
1996
Highly Cited
1996
Leptin, a hormone secreted by adipocytes, regulates the size of the adipose tissue mass through effects on satiety and energy… Expand
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Highly Cited
1996
Highly Cited
1996
Correction of the obese state induced by genetic leptin deficiency reduces elevated levels of both blood glucose and hypothalamic… Expand
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Highly Cited
1995
Highly Cited
1995
C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body… Expand
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Highly Cited
1995
Highly Cited
1995
The recent positional cloning of the mouse ob gene and its human homology has provided the basis to investigate the potential… Expand
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