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nufenoxole
Known as:
2-(3-(5-methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylpropyl)-2-azabicyclo(2.2.2)octane
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Oxadiazoles
Narrower (1)
SC-27166
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1990
1990
Metabolism and pharmacokinetics of nufenoxole in animals and humans: an example of stereospecific hydroxylation of an isoquinuclidine ring.
C. Cook
,
J. Campion
,
J. Hribar
,
A. Karim
Xenobiotica; the fate of foreign compounds in…
1990
Corpus ID: 38319767
1. Nufenoxole, a novel antidiarrhoeal agent, was well absorbed in rat, monkey and human after oral administration. Systemic…
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1989
1989
Is in vivo dissociation between the antipropulsive and antidiarrheal properties of opioids in rats related to gut selectivity?
A. Megens
,
L. L. Canters
,
F. Awouters
,
C. Niemegeers
Archives internationales de pharmacodynamie et de…
1989
Corpus ID: 22078558
The antipropulsive activity of a series of opioids in the charcoal test was compared with their antidiarrheal activity in the…
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1987
1987
Single- and multiple-dose pharmacokinetics of nufenoxole in healthy human subjects.
R. Brownsill
,
M. Hiley
,
+5 authors
N. Gerry
Xenobiotica; the fate of foreign compounds in…
1987
Corpus ID: 28964919
1. In 12 healthy subjects, after single doses of 20, 40 and 80 mg of nufenoxole, mean peak plasma drug concentrations of 400, 815…
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1985
1985
Nufenoxole, a new antidiarrhoeal agent, inhibits fluid secretion in the human jejunum.
K. Moriarty
,
D. Rolston
,
M. Kelly
,
M. Shield
,
M. Clark
Gut
1985
Corpus ID: 27223616
Nufenoxole is an orally active antidiarrhoeal agent which binds to opioid receptors in the brain and myenteric plexus of the…
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Review
1984
Review
1984
Review of the Involvement of Opiate Receptors in Producing the Central and Peripheral Effects Caused by Two New Antidiarrheal Drugs, Loperamide and SC-27166
C. Mackerer
,
G. Clay
,
P. F. East
1984
Corpus ID: 71384052
A review of the morphinomimetic activities of the antidiarrheal drugs loperamide and nufenoxole (SC-27166) is presented. These…
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1984
1984
Effect of nufenoxole on human colonic prostanoid synthesis, Na-K-ATPase and adenylate cyclase activities.
D. Rachmilewitz
,
F. Karmeli
European Journal of Pharmacology
1984
Corpus ID: 4545150
1980
1980
Dependence liability of two antidiarrheals, nufenoxole and loperamide
A. Korey
,
D. H. Zilm
,
E. Sellers
Clinical pharmacology and therapy
1980
Corpus ID: 35222789
We compared the dependence liabilities of therapeutic doses of nufenoxole and loperamide. Ten subjects received 10 mg nufenoxole…
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