nufenoxole

Known as: 2-(3-(5-methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylpropyl)-2-azabicyclo(2.2.2)octane 
 
National Institutes of Health

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2 relations

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Oxadiazoles

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SC-27166

Papers overview

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1990
1990
Metabolism and pharmacokinetics of nufenoxole in animals and humans: an example of stereospecific hydroxylation of an isoquinuclidine ring.
1. Nufenoxole, a novel antidiarrhoeal agent, was well absorbed in rat, monkey and human after oral administration. Systemic… (More)
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1985
1985
Nufenoxole, a new antidiarrhoeal agent, inhibits fluid secretion in the human jejunum.
Nufenoxole is an orally active antidiarrhoeal agent which binds to opioid receptors in the brain and myenteric plexus of the… (More)
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1984
1984
Effect of nufenoxole on human colonic prostanoid synthesis, Na-K-ATPase and adenylate cyclase activities.
To elucidate the possible mechanism whereby nufenoxole exerts its anti-diarrheal activity, its effects on human colonic… (More)
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1980
1980
Dependence liability of two antidiarrheals, nufenoxole and loperamide.
We compared the dependence liabilities of therapeutic doses of nufenoxole and loperamide. Ten subjects received 10 mg nufenoxole… (More)
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