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nufenoxole

Known as: 2-(3-(5-methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylpropyl)-2-azabicyclo(2.2.2)octane 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Oxadiazoles

Narrower (1)

SC-27166

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1990
1990
Metabolism and pharmacokinetics of nufenoxole in animals and humans: an example of stereospecific hydroxylation of an isoquinuclidine ring.
1. Nufenoxole, a novel antidiarrhoeal agent, was well absorbed in rat, monkey and human after oral administration. Systemic… 
1989
1989
Is in vivo dissociation between the antipropulsive and antidiarrheal properties of opioids in rats related to gut selectivity?
The antipropulsive activity of a series of opioids in the charcoal test was compared with their antidiarrheal activity in the… 
1987
1987
Single- and multiple-dose pharmacokinetics of nufenoxole in healthy human subjects.
1. In 12 healthy subjects, after single doses of 20, 40 and 80 mg of nufenoxole, mean peak plasma drug concentrations of 400, 815… 
1985
1985
Nufenoxole, a new antidiarrhoeal agent, inhibits fluid secretion in the human jejunum.
Nufenoxole is an orally active antidiarrhoeal agent which binds to opioid receptors in the brain and myenteric plexus of the… 
Review
1984
Review
1984
Review of the Involvement of Opiate Receptors in Producing the Central and Peripheral Effects Caused by Two New Antidiarrheal Drugs, Loperamide and SC-27166
A review of the morphinomimetic activities of the antidiarrheal drugs loperamide and nufenoxole (SC-27166) is presented. These… 
1984
1984
Effect of nufenoxole on human colonic prostanoid synthesis, Na-K-ATPase and adenylate cyclase activities.
1980
1980
Dependence liability of two antidiarrheals, nufenoxole and loperamide
We compared the dependence liabilities of therapeutic doses of nufenoxole and loperamide. Ten subjects received 10 mg nufenoxole… 
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