nuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids. [ISBN:0198547684]
National Institutes of Health

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2014
2014
Leishmaniasis is a widespread neglected tropical disease caused by parasites of the Leishmania genus. These parasites express the… (More)
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Highly Cited
2013
Highly Cited
2013
The human HD domain protein SAMHD1 is implicated in the Aicardi-Goutières autoimmune syndrome and in the restriction of HIV-1… (More)
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2011
Highly Cited
2011
The multifunctional Mre11-Rad50-Nbs1 (MRN) protein complex recruits ATM/Tel1 checkpoint kinase and CtIP/Ctp1 homologous… (More)
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Highly Cited
2009
Highly Cited
2009
Maintenance of endoplasmic reticulum (ER) function is achieved in part through Ire1 (inositol-requiring enzyme 1), a… (More)
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Highly Cited
2008
Highly Cited
2008
The Mre11/Rad50/NBS1 (MRN) complex maintains genomic stability by bridging DNA ends and initiating DNA damage signaling through… (More)
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2002
Highly Cited
2002
XPF-ERCC1 is a structure-specific endonuclease involved in nucleotide excision repair, interstrand crosslink repair and… (More)
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2001
2001
RecBCD has two conflicting roles in Escherichia coli. (i) As ExoV, it is a potent double-stranded (ds)DNA exonuclease that… (More)
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Highly Cited
2000
Highly Cited
2000
In a diverse group of organisms that includes Caenorhabditis elegans , Drosophila, planaria, hydra, trypanosomes, fungi and… (More)
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Highly Cited
1998
Highly Cited
1998
The present study describes a technique for quantitation of mRNA in a few isotypic cells obtained from an intact organ structure… (More)
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Highly Cited
1993
Highly Cited
1993
The RecBCD enzyme is a multifunctional enzyme that is essential for homologous recombination in E. coli. In vitro, the RecBCD… (More)
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