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noviose

National Institutes of Health

Papers overview

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Review
2018
Review
2018
  • T. Talele
  • Journal of medicinal chemistry
  • 2018
  • Corpus ID: 4097683
The gem-dimethyl moiety is a structural feature frequently found in many natural products of clinical interest, including, but… 
Review
2008
Review
2008
The 90 kDa heat shock proteins (Hsp90), which are integrally involved in cell signaling, proliferation, and survival, are… 
Highly Cited
2007
Highly Cited
2007
Selective hsp90 inhibitors simultaneously destabilize and deplete key signaling proteins involved in cell proliferation and… 
Highly Cited
2006
Highly Cited
2006
ABSTRACT Novobiocin and clorobiocin are gyrase inhibitors produced by Streptomyces strains. Structurally, the two compounds… 
2005
2005
Aminocoumarin antibiotics are highly potent inhibitors of bacterial gyrase and represent a class of antibiotics that are very… 
2004
2004
Noviose is a key synthon for the construction of novobiocin, a clinically useful antitumor agent that has been shown to inhibit… 
Highly Cited
2000
1986
1986
Novobiocin inhibits semiconservative DNA replication in procaryotes and more specifically DNA gyrase, an enzyme essential for DNA…