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noviose

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
  • T. Talele
  • Journal of medicinal chemistry
  • 2018
  • Corpus ID: 4097683
The gem-dimethyl moiety is a structural feature frequently found in many natural products of clinical interest, including, but… Expand
2015
2015
The first enantioselective total synthesis of fidaxomicin, also known as tiacumicin B or lipiarmycin A3, is reported. This novel… Expand
Highly Cited
2009
Highly Cited
2009
We evaluated whether inhibition of heat shock protein 90 (hsp90) function by novobiocin derivatives could induce the degradation… Expand
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Review
2008
Review
2008
The 90 kDa heat shock proteins (Hsp90), which are integrally involved in cell signaling, proliferation, and survival, are… Expand
Highly Cited
2007
Highly Cited
2007
Selective hsp90 inhibitors simultaneously destabilize and deplete key signaling proteins involved in cell proliferation and… Expand
Highly Cited
2006
Highly Cited
2006
ABSTRACT Novobiocin and clorobiocin are gyrase inhibitors produced by Streptomyces strains. Structurally, the two compounds… Expand
2005
2005
Aminocoumarin antibiotics are highly potent inhibitors of bacterial gyrase and represent a class of antibiotics that are very… Expand
2004
2004
Noviose is a key synthon for the construction of novobiocin, a clinically useful antitumor agent that has been shown to inhibit… Expand
Highly Cited
2000
Highly Cited
2000
A new series of coumarin inhibitors of DNA gyrase B bearing a N-propargyloxycarbamate at C-3' of various 5',5'-dialkylnoviose… Expand
1986
1986
Novobiocin inhibits semiconservative DNA replication in procaryotes and more specifically DNA gyrase, an enzyme essential for DNA… Expand