noviose
National Institutes of Health
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The gem-dimethyl moiety is a structural feature frequently found in many natural products of clinical interest, including, but…
The 90 kDa heat shock proteins (Hsp90), which are integrally involved in cell signaling, proliferation, and survival, are…
Selective hsp90 inhibitors simultaneously destabilize and deplete key signaling proteins involved in cell proliferation and…
ABSTRACT Novobiocin and clorobiocin are gyrase inhibitors produced by Streptomyces strains. Structurally, the two compounds…
Aminocoumarin antibiotics are highly potent inhibitors of bacterial gyrase and represent a class of antibiotics that are very…
Noviose is a key synthon for the construction of novobiocin, a clinically useful antitumor agent that has been shown to inhibit…
Novobiocin inhibits semiconservative DNA replication in procaryotes and more specifically DNA gyrase, an enzyme essential for DNA…