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noviose

 
National Institutes of Health

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Monosaccharides

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2015
2015
Total Synthesis of the Glycosylated Macrolide Antibiotic Fidaxomicin.
The first enantioselective total synthesis of fidaxomicin, also known as tiacumicin B or lipiarmycin A3, is reported. This novel… Expand
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2010
2010
The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily.
NovP is an S-adenosyl-l-methionine-dependent O-methyltransferase that catalyzes the penultimate step in the biosynthesis of the… Expand
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Highly Cited
2009
Highly Cited
2009
Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.
We evaluated whether inhibition of heat shock protein 90 (hsp90) function by novobiocin derivatives could induce the degradation… Expand
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Highly Cited
2007
Highly Cited
2007
New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.
Selective hsp90 inhibitors simultaneously destabilize and deplete key signaling proteins involved in cell proliferation and… Expand
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2006
2006
Structure-Activity Relationships of Aminocoumarin-Type Gyrase and Topoisomerase IV Inhibitors Obtained by Combinatorial Biosynthesis
ABSTRACT Novobiocin and clorobiocin are gyrase inhibitors produced by Streptomyces strains. Structurally, the two compounds… Expand
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2005
2005
Metabolic Engineering of Aminocoumarins: Inactivation of the Methyltransferase Gene cloP and Generation of New Clorobiocin Derivatives in a Heterologous Host
Aminocoumarin antibiotics are highly potent inhibitors of bacterial gyrase and represent a class of antibiotics that are very… Expand
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2004
2004
Synthesis of (-)-noviose from 2,3-O-isopropylidene-D-erythronolactol.
Noviose is a key synthon for the construction of novobiocin, a clinically useful antitumor agent that has been shown to inhibit… Expand
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Highly Cited
2000
Highly Cited
2000
Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115.
A new series of coumarin inhibitors of DNA gyrase B bearing a N-propargyloxycarbamate at C-3' of various 5',5'-dialkylnoviose… Expand
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1986
1986
Novenamine is the active moiety in novobiocin.
Novobiocin inhibits semiconservative DNA replication in procaryotes and more specifically DNA gyrase, an enzyme essential for DNA… Expand
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1962
1962
The biosynthesis of noviose, a branched-chain monosaccharide.
 
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