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Wastewater treatment plants (WWTPs) are one of the main sources of pharmaceuticals and endocrine disrupting compounds in… Expand Drug tolerance likely represents an important barrier to tuberculosis treatment shortening. We previously implicated the… Expand Verapamil has the capability to inhibit and induce cytochrome P450 (CYP) 3A and P‐glycoprotein (P‐gp), but the relative extent… Expand Our objectives were to determine the content of cytochrome P450 (CYP) 3A4, CYP3A5, and P‐glycoprotein and to measure CYP3A4… Expand Our objective was to investigate the inducing effect of repeated oral administration of St John's wort on the jejunal transport… Expand Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying… Expand Pharmacokinetics of verapamil (V) in a dose of 40 mg and its metabolite norverapamil (N) from the new oral drug formulation in a… Expand AIMS
The present study was conducted to evaluate metabolism of the enantiomers of verapamil and norverapamil using a broad range… Expand Multiple in vivo CYP3A4/5 probes have been proposed. We compared verapamil clearance measures (CYP3A4/5 substrate) to the… Expand To study the effects of erythromycin and verapamil on the pharmacokinetics of simvastatin, an inhibitor of 3‐hydroxy‐3… Expand