norpropoxyphene

OBJECTIVE Norpropoxyphene (NP) is a major metabolite of propoxyphene (P), a relatively weak mu-opioid receptor agonist. Toxic… Expand

Plasma concentrations of propoxyphene (P) and its pharmacologically active metabolite norpropoxyphene (NP) were determined in… Expand

Summary: Propoxyphene and its principal metabolite, norpropoxyphene. depressed maximum developed isometric tension (T) and its… Expand

The widely used analgesic propoxyphene is subject to extensive presystemic (first‐pass) biotransformation after oral… Expand

Our purpose was to determine whole‐blood hemodialysis clearances and the effect of hemodialysis on blood propoxyphene… Expand

alpha-d-Propoxyphene and its principle metabolite, alpha-d-norpropoxyphene, were compared pharmacologically to establish their… Expand

Propoxyphene and its major metabolite, norpropoxyphene, have been quantitated in tissue specimens obtained from autopsies of… Expand

The development of a gas‐liquid chromatographic method9 for the measurement of propoxyphene (Darvon) in plasma and extension of… Expand

The disposition of propoxyphene and its major biotransformation product norpropoxyphene was studied in normal subjects following… Expand

Abstract A method employing solvent extraction and gas-liquid chromatography has been developed for the quantitative… Expand