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norclozapine

Known as: 8-chloro-11-piperazin-1-yl-5H-dibenzo(B,E)(1,4)diazepine, N-desmethylclozapine, desmethylclozapine 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Antipsychotic AgentsClozapine
Norclozapine:Mass Concentration:Point in time:Serum/Plasma:QuantitativeNorclozapine:PrThr:Pt:Ser/Plas:Ordanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice—Possible involvement of muscarinic receptors
2010
2010
Plasma Clozapine and Norclozapine in Patients Prescribed Different Brands of Clozapine (Clozaril, Denzapine, and Zaponex)
To investigate the bioequivalence of the three clozapine brands licensed in the United Kingdom, we compared plasma clozapine and… 
2009
2009
The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats
RationaleThe discriminative stimulus properties of clozapine (CLZ) have been studied for decades because it remains the prototype… 
2008
2008
Clozapine toxicity: A discussion of pharmacokinetic factors.
2003
2003
Pharmacokinetics of clozapine and its metabolites in hippocampal HT22 cells.
2001
2001
Simultaneous analysis of clozapine, clomipramine and their metabolites by reversed-phase liquid chromatography
1999
1999
Another use of silica gel and aqueous eluent for HPLC analysis of clozapine and desmethylclozapine.
A procedure that involves a high-performance liquid chromatographic system with silica-bonded columns and reversed-phase eluents… 
1996
1996
The moderate affinity of clozapine at H3 receptors is not shared by its two major metabolites and by structurally related and unrelated atypical neuroleptics
We determined the affinity and/or potency of two metabolites of clozapine (clozapine-N-oxide and N-desmethylclozapine) and of… 
1995
1995
Measurement of clozapine and norclozapine in plasma/serum by high performance liquid chromatography with ultraviolet detection.
A simple method for the measurement of clozapine and its N-desmethyl metabolite in human plasma or serum by high performance… 
1995
1995
The use of clozapine plasma levels in optimising therapy
Clozapine is well known to be an effective treatment for neuroleptic-resistant schizophrenia. However, its use is complicated by… 
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