nimesulide

Known as: R 805, 4-nitro-2-phenoxymethanesulfonanilide, N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide 
A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Drug-induced liver injury (DILI) is the most common adverse event causing drug nonapprovals and drug withdrawals. Using drugs as… (More)
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Highly Cited
2004
Highly Cited
2004
The purpose of this research was to develop mouth dissolve tablets of nimesulide. Granules containing nimesulide, camphor… (More)
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Highly Cited
2003
Highly Cited
2003
Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE To estimate the risk of acute hepatotoxicity associated with nimesulide compared with other non-steroidal anti… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE A niosome based transdermal drug delivery system of Nimesulide (NIM) was developed and extensively characterized and… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAID) may be useful in the treatment of AD. Clinical and laboratory experience… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The formation of prostacyclin (PGI(2)), thromboxane (TX) A(2), and isoprostanes is markedly enhanced in… (More)
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Highly Cited
1998
Highly Cited
1998
Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox… (More)
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1995
1995
Prostaglandins are pro-inflammatory but are gastroprotective. The gastric mucosa synthesizes prostaglandins mainly via… (More)
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1987
1987
Oxygen derived free radical release from activated neutrophils may be in part responsible of tissue damage in the acute phase of… (More)
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