nicotinic receptor alpha4beta2

Background and purpose:  Smoking cessation trials with three high‐affinity partial agonists of α4β2 neuronal nicotinic… Expand

CONTEXT Cognitive or depressive disorders are frequently noted in patients with Parkinson disease (PD) and may be related to… Expand

The identification and characterization of drugs for the treatment of cognitive disorders has been hampered by the absence of… Expand

Adolescence is a time of significant brain development, and exposure to nicotine during this period is associated with higher… Expand

alpha4beta2 nicotinic acetylcholine receptors (nAChRs) are recognized as the principal nicotine binding site in brain… Expand

The subtype-specificity of newly synthesised epibatidine-related compounds, norchloro-fluoro-homoepibatidine (NCFHEB) and… Expand

In the past few years the focus on central acetylcholine receptors has shifted from compounds with affinity for muscarinic… Expand

To extend our knowledge of the pharmacological profile of human alpha4beta2 neuronal nicotinic receptors, we investigated the… Expand

A mutation (S247F) in the channel-lining domain (M2) of the α4 nicotinic acetylcholine receptor (AChR) subunit has previously… Expand

Because chronic exposure to nicotine and nicotinic drugs might both activate and desensitize nicotinic acetylcholine receptors… Expand