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nicotinic receptor alpha4beta2

Known as: receptor, nicotinic alpha4beta2, nAChRalpha4beta2, nicotinic receptors alpha4beta2 
National Institutes of Health

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Broader (1)

Nicotinic Receptors

Papers overview

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Highly Cited
2010
Highly Cited
2010
Pre‐clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence
Background and purpose:  Smoking cessation trials with three high‐affinity partial agonists of α4β2 neuronal nicotinic… 
Highly Cited
2009
Highly Cited
2009
Reduced alpha4beta2*-nicotinic acetylcholine receptor binding and its relationship to mild cognitive and depressive symptoms in Parkinson disease.
CONTEXT Cognitive or depressive disorders are frequently noted in patients with Parkinson disease (PD) and may be related to… 
Review
2009
Review
2009
nAChR agonist-induced cognition enhancement: integration of cognitive and neuronal mechanisms.
Review
2009
Review
2009
The road to discovery of neuronal nicotinic cholinergic receptor subtypes.
The discovery that mammalian brain expresses the mRNAs for nine different nicotinic cholinergic receptor subunits (alpha2-alpha7… 
Highly Cited
2008
Highly Cited
2008
Adult and periadolescent rats differ in expression of nicotinic cholinergic receptor subtypes and in the response of these subtypes to chronic nicotine exposure
2004
2004
Norchloro-fluoro-homoepibatidine: specificity to neuronal nicotinic acetylcholine receptor subtypes in vitro.
Highly Cited
2000
Highly Cited
2000
Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis.
In the past few years the focus on central acetylcholine receptors has shifted from compounds with affinity for muscarinic… 
Highly Cited
1998
Highly Cited
1998
Open-channel blockers at the human alpha4beta2 neuronal nicotinic acetylcholine receptor.
To extend our knowledge of the pharmacological profile of human alpha4beta2 neuronal nicotinic receptors, we investigated the… 
Highly Cited
1997
Highly Cited
1997
Mutation Causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Alters Ca2+ Permeability, Conductance, and Gating of Human α4β2 Nicotinic Acetylcholine Receptors
A mutation (S247F) in the channel-lining domain (M2) of the α4 nicotinic acetylcholine receptor (AChR) subunit has previously… 
Highly Cited
1997
Highly Cited
1997
Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes.
Because chronic exposure to nicotine and nicotinic drugs might both activate and desensitize nicotinic acetylcholine receptors… 
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