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nicotinate-nucleotide pyrophosphorylase (carboxylating) activity
, nicotinate-nucleotide diphosphorylase (carboxylating) activity
, quinolinate phosphoribosyltransferase (decarboxylating) activity
Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate. [EC:2.4…
National Institutes of Health
nicotinamide-nucleotide adenylyltransferase activity
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Quinolinic acid catabolism is increased in cerebellum of patients with dominantly inherited olivopontocerebellar atrophy.
Stephen J. Kish
Robert M. Schwarcz
Annals of neurology
Corpus ID: 44800724
We measured the activities of the enzymes responsible for the metabolism of the excitotoxin quinolinic acid, 3…
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