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nicotinamide phosphoribosyltransferase, human

Known as: PBEF, human, Pre-B Cell-Enhancing Factor, pre-B-cell colony-enhancing factor, human 
Nicotinamide phosphoribosyltransferase (491 aa, ~56 kDa) is encoded by the human NAMPT gene. This protein plays a role in both NAD biosynthesis and… 
National Institutes of Health

Related topics

Related topics

13 relations
Carbohydrate MetabolismCytokine GeneCytokine Receptor BindingCytokine Signaling

Broader (2)

Nicotinamide Phosphoribosyltransferasecytokine

Papers overview

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Highly Cited
2016
Highly Cited
2016
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.
Highly Cited
2012
Highly Cited
2012
Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells
Background: NAMPT catalyzes the rate-limiting reaction in converting nicotinamide to NAD+ in cancers. Results: NAMPT inhibition… 
Highly Cited
2012
Highly Cited
2012
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia
Recent reports indicate that autophagy serves as a stress response and may participate in pathophysiology of cerebral ischemia… 
Highly Cited
2011
Highly Cited
2011
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
Highly Cited
2008
Highly Cited
2008
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.
Highly Cited
2008
Highly Cited
2008
Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis.
AIMS Visfatin is a novel adipokine whose plasma concentrations are altered in obesity and obesity-related disorders; these states… 
Highly Cited
2008
Highly Cited
2008
Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase.
Human nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12) catalyzes the reversible synthesis of nicotinamide… 
Highly Cited
2007
Highly Cited
2007
Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival
Review
2007
Review
2007
The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals
Purpose of reviewNicotinamide adenine dinucleotide (NAD) is a classic coenzyme in cellular redox reactions. Recently, NAD… 
Highly Cited
2006
Highly Cited
2006
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD… 
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