neurofibrillary tangle assembly

Known as: neurofibrillary tangle formation 
The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle. [GO_REF:0000079, GOC:sjp, GOC:TermGenie… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
Brains of 42 individuals between the ages of 4 and 29 were examined with antibodies (AT8, 4G8) and silver stains for the presence… (More)
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Highly Cited
2006
Highly Cited
2006
Glycogen synthase kinase-3 (GSK-3) has been proposed as the main kinase able to aberrantly phosphorylate tau in Alzheimer's… (More)
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Highly Cited
2005
Highly Cited
2005
Here, we describe the generation of a novel transgenic mouse model of human tauopathy. The rTg(tau(P301L))4510 mouse expresses… (More)
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Highly Cited
2004
Highly Cited
2004
Alzheimer's disease (AD) includes etiologically heterogeneous disorders characterized by senile or presenile dementia… (More)
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Highly Cited
2001
Highly Cited
2001
The microtubule-binding protein tau has been implicated in the pathogenesis of Alzheimer's disease and related disorders. However… (More)
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Highly Cited
1997
Highly Cited
1997
OBJECTIVE To determine initial locus and rate of degeneration of temporal lobe structures (total lobe, hippocampus and… (More)
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Highly Cited
1997
Highly Cited
1997
The total numbers of neurons with and without neurofibrillary changes in the hippocampal subdivisions were estimated in 16… (More)
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Highly Cited
1995
Highly Cited
1995
ALZHEIMER'S disease (AD) is the most common cause of progressive intellectual failure in aged humans. AD brains contain numerous… (More)
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Highly Cited
1992
Highly Cited
1992
We report the results of an examination of the elemental content of neurofibrillary tangle-bearing and neurofibrillary tangle… (More)
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Highly Cited
1982
Highly Cited
1982
We have made a histological study of the cerebral cortex and hippocampus from 59 consecutively autopsied subjects, aged 51-102… (More)
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