negative regulation of thymidylate synthase biosynthetic process

Known as: negative regulation of thymidylate synthase anabolism, negative regulation of thymidylate synthase biosynthesis, down-regulation of thymidylate synthase biosynthetic process 
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2018
051019832018

Papers overview

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Highly Cited
2010
Highly Cited
2010
Thymidylate synthase (TYMS) is a target of the most widely used chemotherapeutic agents against gastrointestinal malignancies… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Predicting efficacy and toxicity could potentially allow individualization of cancer therapy. We investigated putative… (More)
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2006
2006
Thymidylate synthase (TS) overexpression is a key determinant of 5-fluorouracil (5-FU) resistance in human cancer cells. TS is… (More)
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Highly Cited
2003
Highly Cited
2003
Thymidylate synthase (TS) gene expression is modulated by a polymorphism in the 5' regulatory region of the gene. The… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE The aim of this multicenter prospective study was to evaluate the role of intratumoral parameters related to fluorouracil… (More)
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Highly Cited
2001
Highly Cited
2001
Thymidylate synthase (TS) catalyses the conversion of deoxy-uridylate to deoxy-thymidylate and is essential for DNA synthesis… (More)
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Highly Cited
2001
Highly Cited
2001
Thymidylate synthase (TS) is an important target for chemotherapy drugs such as 5-fluorouracil and raltitrexed. Over-expression… (More)
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2001
2001
Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized… (More)
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2000
2000
Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target of cancer chemotherapy… (More)
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1996
1996
3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (AG337) is a water-soluble, lipophilic inhibitor… (More)
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