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negative regulation of thymidylate synthase biosynthetic process

Known as: negative regulation of thymidylate synthase anabolism, negative regulation of thymidylate synthase biosynthesis, down-regulation of thymidylate synthase biosynthetic process 
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the… 
National Institutes of Health

Papers overview

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Review
2013
Review
2013
Viruses are fundamental to ecosystems ranging from oceans to humans, yet our ability to study them is bottlenecked by the lack of… 
Highly Cited
2003
Highly Cited
2003
PURPOSE The aim of this study was to investigate the utility of quantitating thymidylate synthase (TS) in the primary tumor as a… 
Highly Cited
2002
Highly Cited
2002
Structural genomics is emerging as a principal approach to define protein structure–function relationships. To apply this… 
Highly Cited
1997
Highly Cited
1997
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors… 
Highly Cited
1997
Highly Cited
1997
PURPOSE Response rates to fluorouracil (5-FU)-based therapy remain low. As new, active agents are being tested, information… 
Highly Cited
1990
Highly Cited
1990
Cycloguanil, the active metabolite of the antimalarial drug proguanil, is an inhibitor of dihydrofolate reductase as is another… 
Highly Cited
1990
Highly Cited
1990
The structure of thymidylate synthase (TS) from Escherichia coli was solved from cubic crystals with a = 133 Å grown under… 
Highly Cited
1985
Highly Cited
1985
We studied the content and metabolism of thymidylate synthase mRNA in cultured mouse fibroblasts that were undergoing a serum…