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negative regulation of thymidylate synthase biosynthetic process

Known as: negative regulation of thymidylate synthase anabolism, negative regulation of thymidylate synthase biosynthesis, down-regulation of thymidylate synthase biosynthetic process 
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Thymidylate synthase (TS) intratumoural expression may be a prognostic marker and predict outcome of 5-fluorouracil (5-FU)-based… Expand
Highly Cited
2004
Highly Cited
2004
Sequence analysis of the 330-kb double-stranded DNA genome of Paramecium bursaria chlorella virus-1 revealed an open reading… Expand
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Highly Cited
2003
Highly Cited
2003
PURPOSE The aim of this study was to investigate the utility of quantitating thymidylate synthase (TS) in the primary tumor as a… Expand
Highly Cited
2002
Highly Cited
2002
Structural genomics is emerging as a principal approach to define protein structure–function relationships. To apply this… Expand
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Highly Cited
1997
Highly Cited
1997
PURPOSE Response rates to fluorouracil (5-FU)-based therapy remain low. As new, active agents are being tested, information… Expand
Highly Cited
1997
Highly Cited
1997
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors… Expand
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Highly Cited
1997
Highly Cited
1997
The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI… Expand
Highly Cited
1995
Highly Cited
1995
A clinical trial for patients with measurable, disseminated colorectal cancer is being conducted to determine: (1) if… Expand
Highly Cited
1990
Highly Cited
1990
Cycloguanil, the active metabolite of the antimalarial drug proguanil, is an inhibitor of dihydrofolate reductase as is another… Expand
Highly Cited
1990
Highly Cited
1990
The structure of thymidylate synthase (TS) from Escherichia coli was solved from cubic crystals with a = 133 Å grown under… Expand