negative regulation of positive thymic T cell selection

Known as: down regulation of positive thymic T cell selection, downregulation of positive thymic T lymphocyte selection, downregulation of positive thymic T cell selection 
Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection. [GOC:TermGenie, PMID:22080863]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2017
0204019672017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Since the days of the ancient Greeks, the pathologic hallmarks of malignancy have been reflected in the language of oncology… (More)
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Although tumor development requires impaired apoptosis, we describe a novel paradigm of apoptosis-dependent tumorigenesis… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
The ability to mount protective immune responses depends on the diversity of T cells. T cell diversity may be compromised by the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Age-associated thymic involution is accompanied by decreased thymic output. This adversely affects general immune competence and… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The ability to measure human thymic output would be an invaluable tool for the study of the development of the naive T cell… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Interleukin (IL)-12 may be secreted as a bioactive T helper type 1 (Th1) cell-inducing heterodimer, as a monomer, or as an… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 6
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The present report provides the first extensive characterization of the OT-I TCR transgenic line, which produces MHC class I… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
T-cell development is under the tight control of thymic microenvironments. Conversely, the integrity of thymic microenvironments… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Dendritic cells (DCs) are a heterogeneous population of cells that are specialized for Ag processing and presentation. These… (More)
  • figure 1
  • table I
  • figure 2
Is this relevant?
Highly Cited
2000
Highly Cited
2000
We show that the mesenchymal cells that surround the 12-d mouse embryo thymus are necessary for T cell differentiation. Thus… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?