negative regulation of inositol trisphosphate biosynthetic process
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The phosphoinositide phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) plays crucial roles in the maintenance of lysosome/vacuole… Expand Abbreviations: PKC, protein kinase C; cPLA2, cytosol palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPS, 1 3-phosphoserine; PI… Expand Although the essential genes for autophagy (Atg) have been identified, the molecular mechanisms through which Atg proteins… Expand Mechanical and osmotic sensitivity of the transient receptor potential vanilloid 4 (TRPV4) channel depends on phospholipase A2… Expand Calcium (Ca2+) release from intracellular stores plays a crucial role in many cellular functions in the brain. These… Expand Inositol lipid-derived second messengers have long been known to have an important regulatory role in cell physiology… Expand The CD38 cell surface receptor is a potent activator for splenic, B lymphocytes. The molecular mechanisms regulating this… Expand SHIP-2 is a phosphoinositidylinositol 3,4,5 trisphosphate (PtdIns[3,4,5]P3) 5-phosphatase that contains an NH2-terminal SH2… Expand The activation of the protease-activated receptor 1 (PAR-1) by thrombin has been shown to induce an activation of the MAP kinase… Expand Myoinositol trisphosphate (IP3) is formed when phosphatidylinositol 4,5-bisphosphate (PIP2) is hydrolyzed by phospholipase C. At… Expand