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negative regulation of germinal center formation

Known as: down regulation of germinal center formation, down-regulation of germinal center formation, downregulation of germinal center formation 
Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation. [GOC:add]
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

biological control
germinal center formation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal Mice
Immaturity of the immune system contributes to poor vaccine responses in early life. Germinal center (GC) activation is limited… Expand
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Review
2018
Review
2018
The Transcriptional Regulation of Germinal Center Formation
Germinal centers (GCs) are essential structures of the humoral immune response, which form in the periphery in response to T cell… Expand
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2018
2018
B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle
Although TLR signaling in B cells has been implicated in the germinal center (GC) responses during viral infections and… Expand
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Highly Cited
2017
Highly Cited
2017
Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
Summary During antibody affinity maturation, germinal center (GC) B cells cycle between affinity‐driven selection in the light… Expand
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Highly Cited
2015
Highly Cited
2015
The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program.
The pathways regulating formation of the germinal center (GC) dark zone (DZ) and light zone (LZ) are unknown. In this study we… Expand
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2015
2015
TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation
Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR… Expand
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Review
2014
Review
2014
Evaluation of Germinal Center-like Structures and B Cell Clonality in Patients with Primary Sjögren Syndrome with and without Lymphoma
Objective. Germinal center (GC)-like structures have previously been observed in minor salivary glands (MSG) of patients with… Expand
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1998
1998
Gap-Junction Communication Pathways in Germinal Center Reactions
Intercellular channels called gap junctions enable multicellular organisms to exchange information rapidly between cells. Though… Expand
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Highly Cited
1997
Highly Cited
1997
Paracrine Regulation of Germinal Center B Cell Adhesion through the c-Met–Hepatocyte Growth Factor/Scatter Factor Pathway
T cell–dependent humoral immune responses are initiated by the activation of naive B cells in the T cell areas of the secondary… Expand
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Highly Cited
1997
Highly Cited
1997
Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells.
Bcl-2 suppresses drug-induced apoptosis in vitro, although in many cases, this results only in a delayed onset of cell death. In… Expand
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