negative regulation of germinal center formation
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Immaturity of the immune system contributes to poor vaccine responses in early life. Germinal center (GC) activation is limited… Expand Germinal centers (GCs) are essential structures of the humoral immune response, which form in the periphery in response to T cell… Expand Although TLR signaling in B cells has been implicated in the germinal center (GC) responses during viral infections and… Expand Summary During antibody affinity maturation, germinal center (GC) B cells cycle between affinity‐driven selection in the light… Expand The pathways regulating formation of the germinal center (GC) dark zone (DZ) and light zone (LZ) are unknown. In this study we… Expand Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR… Expand Objective. Germinal center (GC)-like structures have previously been observed in minor salivary glands (MSG) of patients with… Expand Intercellular channels called gap junctions enable multicellular organisms to exchange information rapidly between cells. Though… Expand T cell–dependent humoral immune responses are initiated by the activation of naive B cells in the T cell areas of the secondary… Expand Bcl-2 suppresses drug-induced apoptosis in vitro, although in many cases, this results only in a delayed onset of cell death. In… Expand