negative regulation of estrogen biosynthetic process
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Acquired tamoxifen (TAM) resistance limits the therapeutic benefit of TAM in patients with hormone‐dependent breast cancer. The… Expand Excess androgen synthesis by thecal cells is invariably detrimental to preovulatory follicles in the ovary and is considered a… Expand Aims/hypothesisWe used oestrogen receptor-α (ERα) knockout (ERKO) and receptor-β (ERβ) knockout (BERKO) mice to investigate the… Expand For many years, tamoxifen has been the 'gold standard' amongst anti-oestrogen therapies for breast cancer. However, the selective… Expand Eggshell thinning among wild birds has been an environmental concern for almost half a century. Although the mechanisms for… Expand Exposure to oestrogenic chemicals (xeno-oestrogens) may have severe effects on embryonic development. The present study… Expand The biology and physiology of the male as well as female reproductive system is hormonally regulated. Abnormalities in the… Expand The mechanisms underlying loss of oestrogen responsiveness in breast cancer are not well-defined. Potential mechanisms include… Expand Oestrogen sulphatase may play an important role in providing intracellular oestrogens from E1S for the growth and maintenance of… Expand Various oestrogen responsive reporter genes and vectors expressing truncated or chimeric human oestrogen receptors (hER… Expand