negative regulation of death-inducing signaling complex assembly

Known as: down regulation of DISC assembly, downregulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway, negative regulation of death-inducing signalling complex assembly 
Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly. [GO_REF:0000058, GOC:bf, GOC… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
The death-inducing signaling complex (DISC) formed by the death receptor Fas, the adaptor protein FADD and caspase-8 mediates the… (More)
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Highly Cited
2008
Highly Cited
2008
Mre11 forms the core of the multifunctional Mre11-Rad50-Nbs1 (MRN) complex that detects DNA double-strand breaks (DSBs… (More)
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Highly Cited
2008
Highly Cited
2008
The spindle assembly checkpoint (SAC) is required to block sister chromatid separation until all chromosomes are properly… (More)
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Highly Cited
2006
Highly Cited
2006
Mitotic spindle morphogenesis is a series of highly coordinated movements that lead to chromosome segregation and cytokinesis. We… (More)
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Highly Cited
2005
Highly Cited
2005
In response to nutrients, energy sufficiency, hormones, and mitogenic agents, S6K1 phosphorylates several targets linked to… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND The spindle assembly checkpoint (SAC) imparts fidelity to chromosome segregation by delaying anaphase until all sister… (More)
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Highly Cited
2004
Highly Cited
2004
Mature microRNAs (miRNAs) are generated via a two-step processing pathway to yield ∼22-nucleotide small RNAs that regulate gene… (More)
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Highly Cited
2002
Highly Cited
2002
The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large… (More)
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Highly Cited
1999
Highly Cited
1999
Chromatin assembly is a fundamental biological process that is essential for the replication and maintenance of the eukaryotic… (More)
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Highly Cited
1996
Highly Cited
1996
The spindle assembly checkpoint delays anaphase until all chromosomes are attached to a mitotic spindle. The mad (mitotic arrest… (More)
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