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negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation

Known as: cyclin catabolism, cyclin degradation, cyclin catabolic process 
The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and… Expand
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Cyclin D1 plays a critical role in controlling the G1/S transition via the regulation of cyclin-dependent kinase activity… Expand
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Highly Cited
2007
Highly Cited
2007
Transformation and cancer growth are regulated by the coordinate actions of oncogenes and tumor suppressors. Here, we show that… Expand
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Highly Cited
2002
Highly Cited
2002
Cyclin B1, the regulatory component of M phase-promoting factor (MPF), is degraded during the metaphase-anaphase transition in an… Expand
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Highly Cited
2001
Highly Cited
2001
In Saccharomyces cerevisiae, the phosphoprotein phosphatase Cdc14p plays a central role in exit from mitosis, by promoting B-type… Expand
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Highly Cited
2000
Highly Cited
2000
In two independent screens we isolated fission yeast mutations with phenotypes suggesting defects in B-cyclin function or… Expand
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Highly Cited
1995
Highly Cited
1995
Cln3 cyclin of the budding yeast Saccharomyces cerevisiae is a key regulator of Start, a cell cycle event in G1 phase at which… Expand
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Highly Cited
1992
Highly Cited
1992
Exit from metaphase of the cell cycle requires inactivation of MPF, a stoichiometric complex between the cdc2 catalytic and the… Expand
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Highly Cited
1991
Highly Cited
1991
A derivative of ubiquitin in which amino groups were blocked by reductive methylation was used to study the possible role of the… Expand
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Highly Cited
1991
Highly Cited
1991
Exit from M phase, which requires cyclin degradation, is prevented from occurring in unfertilized eggs of vertebrates arrested at… Expand
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Highly Cited
1990
Highly Cited
1990
THE cell cycles of early Xenopus embryos consist of a rapid succession of alternating S and M phases1. These cycles are… Expand
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