negative regulation of DNA-directed DNA polymerase activity

Known as: negative regulation of deoxyribonucleic acid duplicase activity, inhibition of DNA-dependent DNA polymerase activity, down-regulation of deoxyribonucleic acid duplicase activity 
Any process that stops, prevents or reduces the frequency, rate or extent of DNA-directed DNA polymerase activity. [GOC:TermGenie]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1952-2017
020040019522016

Papers overview

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Highly Cited
2013
Highly Cited
2013
As more clinically relevant cancer genes are identified, comprehensive diagnostic approaches are needed to match patients to… (More)
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Highly Cited
2012
Highly Cited
2012
Unlike activated CD4+ T cells, resting CD4+ T cells are highly resistant to productive HIV-1 infection. Early after HIV-1 entry… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Massively parallel DNA sequencing of cell-free fetal DNA from maternal blood can detect fetal chromosomal… (More)
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Highly Cited
2010
Highly Cited
2010
Next-generation DNA sequencing (NGS) projects, such as the 1000 Genomes Project, are already revolutionizing our understanding of… (More)
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Highly Cited
2008
Highly Cited
2008
MicroRNAs (miRNAs) have been implicated in sequence-specific cleavage, translational repression or deadenylation of specific… (More)
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Highly Cited
2007
Highly Cited
2007
Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an increased risk of breast and ovarian cancers… (More)
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Highly Cited
2005
Highly Cited
2005
Genomic DNA was amplified about 5 billion-fold from single, flow-sorted bacterial cells by the multiple displacement… (More)
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Highly Cited
2004
Highly Cited
2004
DNA methyltransferase 1 (DNMT1) is required to maintain DNA methylation patterns in mammalian cells, and is thought to be the… (More)
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Highly Cited
2000
Highly Cited
2000
Breast cancer cell lines provide a useful starting point for the discovery and functional analysis of genes involved in breast… (More)
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Highly Cited
1986
Highly Cited
1986
The ability of tumor cells to develop simultaneous resistance to structurally different cytotoxic drugs constitutes a major… (More)
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