negamycin

 
National Institutes of Health

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Amino Acids, Diamino

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2014
2014
Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.
Negamycin (NEG) is a ribosome-targeting antibiotic that exhibits clinically promising activity. Its binding site and mode of… (More)
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2014
2014
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Negamycin is a natural product with broad-spectrum antibacterial activity and efficacy in animal models of infection. Although… (More)
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2012
2012
Negamycin analogue with readthrough-promoting activity as a potential drug candidate for duchenne muscular dystrophy.
A series of (+)-negamycin 1 analogues were synthesized, and their readthrough-promoting activity was evaluated for nonsense… (More)
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2008
2008
Drug-induced readthrough of premature stop codons leads to the stabilization of laminin alpha2 chain mRNA in CMD myotubes.
BACKGROUND The most common form of congenital muscular dystrophy is caused by a deficiency in the alpha2 chain of laminin-211, a… (More)
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2007
2007
Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit.
Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a single… (More)
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2003
2003
Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice.
The ability of aminoglycoside antibiotics to promote read-through of nonsense mutations has attracted interest in these drugs as… (More)
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2003
2003
N- and C-terminal modifications of negamycin.
Negamycin 1 is a bactericidal antibiotic with activity against Gram-negative bacteria, and served as a template in an antibiotic… (More)
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2003
2003
Negamycin-therapy in Skeletal and Cardiac Muscles of mdx Mice
The ability of aminoglycoside antibiotics to promote read-through of nonsense mutations has attracted interest in these drugs as… (More)
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1976
1976
Structure-activity relationships among negamycin analogs.
Various negamycin analogs were examined for (1) miscoding activity and (2) inhibition of the termination of protein synthesis… (More)
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1976
1976
Specific inhibition of the termination process of protein synthesis by negamycin.
The effect of negamycin and its derivatives on protein synthesis in an Escherichia coli cell-free system was determined. (1… (More)
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