negamycin
National Institutes of Health
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Significance The identification of negamycin’s binding site within helix 34 of the small subunit head domain and the elucidation…
The APC tumor suppressor gene is frequently mutated in human colorectal cancer, with nonsense mutations accounting for 30% of all…
The most common form of congenital muscular dystrophy is caused by a deficiency in the α2 chain of laminin‐211, a protein of the…
ABSTRACT Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a…
The ability of aminoglycoside antibiotics to promote read-through of nonsense mutations has attracted interest in these drugs as…
Various negamycin analogs were examined for (1) miscoding activity and (2) inhibition of the termination of protein synthesis…
Using various in vivo and in vitro systems, Mizuno et al.3>i} demonstrated that negamycin is a specific inhibitor of protein…