negamycin

Negamycin (NEG) is a ribosome-targeting antibiotic that exhibits clinically promising activity. Its binding site and mode of… Expand

The most common form of congenital muscular dystrophy is caused by a deficiency in the α2 chain of laminin‐211, a protein of the… Expand

ABSTRACT Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a… Expand

The ability of aminoglycoside antibiotics to promote read-through of nonsense mutations has attracted interest in these drugs as… Expand

Negamycin 1 is a bactericidal antibiotic with activity against Gram-negative bacteria, and served as a template in an antibiotic… Expand

The effect of negamycin and its derivatives on protein synthesis in an Escherichia coli cell-free system was determined. (1… Expand

Various negamycin analogs were examined for (1) miscoding activity and (2) inhibition of the termination of protein synthesis… Expand

Abstract In the presence of negamycin, the amount of ribosome-bound peptides during protein synthesis increased to 2 or 3 times… Expand