necroptotic process

Known as: necroptosis 
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like… (More)
National Institutes of Health

Related topics

Related topics

6 relations
Negative Regulation of Cell Deathparthanatosregulation of necroptotic process

Broader (2)

activation of necroptosisprogrammed necrotic cell death

Narrower (1)

necroptotic signaling pathway

Papers overview

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Review
2017
Review
2017
Initiation and execution mechanisms of necroptosis: an overview
Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF family death domain receptors, pattern… (More)
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Review
2017
Review
2017
Programmed cell death as a defence against infection
Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell… (More)
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Highly Cited
2014
Highly Cited
2014
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
Necroptosis is considered to be complementary to the classical caspase-dependent programmed cell death pathway, apoptosis. The… (More)
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Highly Cited
2014
Highly Cited
2014
RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.
AIMS Programmed necrosis (necroptosis) represents a newly identified mechanism of cell death combining features of both apoptosis… (More)
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Review
2014
Review
2014
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled… (More)
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Highly Cited
2013
Highly Cited
2013
Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling.
Receptor interacting protein 3 (RIP3) is a protein kinase essential for TNF-induced necroptosis. Phosphorylation on Ser-227 in… (More)
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Review
2010
Review
2010
Molecular mechanisms of necroptosis: an ordered cellular explosion
For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease… (More)
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Highly Cited
2008
Highly Cited
2008
Identification of RIP1 kinase as a specific cellular target of necrostatins.
Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor… (More)
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Highly Cited
2007
Highly Cited
2007
Shikonin circumvents cancer drug resistance by induction of a necroptotic death.
Defect in apoptotic signaling and up-regulation of drug transporters in cancer cells significantly limits the effectiveness of… (More)
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Highly Cited
2005
Highly Cited
2005
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms… (More)
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