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navitoclax

An orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Clearing senescent cells extends healthspan in mice. Using a hypothesis‐driven bioinformatics‐based approach, we recently… Expand
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Highly Cited
2015
Highly Cited
2015
The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL… Expand
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Highly Cited
2013
Highly Cited
2013
Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises… Expand
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Highly Cited
2012
Highly Cited
2012
PURPOSE BCL2 overexpression is a hallmark of chronic lymphocytic leukemia (CLL). The novel BH3 mimetic navitoclax (ABT-263… Expand
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Highly Cited
2012
Highly Cited
2012
Purpose: Bcl-2 is a critical regulator of apoptosis that is overexpressed in the majority of small cell lung cancers (SCLC… Expand
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Highly Cited
2012
Highly Cited
2012
  • M. Baker
  • Nature Reviews Drug Discovery
  • 2012
  • Corpus ID: 5740225
With multiple drug candidates in the clinic that originated from fragment-based lead discovery, the approach of starting small… Expand
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Highly Cited
2012
Highly Cited
2012
The BH3-mimetic ABT-737 and an orally bioavailable compound of the same class, navitoclax (ABT-263), have shown promising… Expand
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Highly Cited
2012
Highly Cited
2012
  • A. Mullard
  • Nature Reviews Drug Discovery
  • 2012
  • Corpus ID: 39902684
Drug developers are getting closer to tapping an unmined gold reserve of protein–protein interaction targets. 
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Highly Cited
2011
Highly Cited
2011
PURPOSE Resistance to chemotherapy-induced apoptosis represents a major obstacle to cancer control. Overexpression of Bcl-2 is… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Proteins of the BCL-2 family regulate clonal selection and survival of lymphocytes, and are frequently overexpressed… Expand
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