navitoclax

An orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2018
0102020032018

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2016
2016
Clearing senescent cells extends healthspan in mice. Using a hypothesis-driven bioinformatics-based approach, we recently… (More)
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2015
Highly Cited
2015
The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL… (More)
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2013
Highly Cited
2013
Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE BCL2 overexpression is a hallmark of chronic lymphocytic leukemia (CLL). The novel BH3 mimetic navitoclax (ABT-263… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE Bcl-2 is a critical regulator of apoptosis that is overexpressed in the majority of small cell lung cancers (SCLC… (More)
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2012
Highly Cited
2012
The BH3-mimetic ABT-737 and an orally bioavailable compound of the same class, navitoclax (ABT-263), have shown promising… (More)
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2012
2012
To examine the potential of combining Bcl-2 family inhibitors with chemotherapy in ovarian cancer, we evaluated a panel of 27… (More)
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2011
2011
PURPOSE To explore the potential of navitoclax in combination with taxane-based chemotherapy in the treatment of non-small cell… (More)
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2011
2011
Combining microtubule-targeting antimitotic drugs with targeted apoptosis potentiators is a promising new chemotherapeutic… (More)
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2010
Highly Cited
2010
BACKGROUND Proteins of the BCL-2 family regulate clonal selection and survival of lymphocytes, and are frequently overexpressed… (More)
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