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natalizumab

Known as: Anti-VLA4, Anti-alpha4 integrin, Natalizumab [Chemical/Ingredient] 
A humanized recombinant IgG4 monoclonal antibody directed against the alpha4 subunit of the integrins alpha4beta1and alpha4beta7 with… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Progressive multifocal leukoencephalopathy (PML) is associated with natalizumab treatment. We quantified the risk of… Expand
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Review
2010
Review
2010
BACKGROUND Treatment of multiple sclerosis with natalizumab is complicated by rare occurrence of progressive multifocal… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND & AIMS A randomized placebo-controlled trial evaluated the efficacy of natalizumab induction therapy in patients with… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Natalizumab is the first alpha4 integrin antagonist in a new class of selective adhesion-molecule inhibitors. We… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Interferon beta is used to modify the course of relapsing multiple sclerosis. Despite interferon beta therapy, many… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Natalizumab, a humanized monoclonal antibody against alpha4 integrin, inhibits leukocyte adhesion and migration into… Expand
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Highly Cited
2005
Highly Cited
2005
A 46-year-old woman with relapsing-remitting multiple sclerosis died from progressive multifocal leukoencephalopathy (PML) after… Expand
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Highly Cited
2005
Highly Cited
2005
We describe the clinical course of a patient with multiple sclerosis in whom progressive multifocal leukoencephalopathy (PML), an… Expand
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Highly Cited
2005
Highly Cited
2005
The prior diagnosis of fatal astrocytoma in a 60-year-old man with Crohn's disease treated with natalizumab, a monoclonal… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND In patients with multiple sclerosis, inflammatory brain lesions appear to arise from autoimmune responses involving… Expand
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