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natalizumab

Known as: Anti-VLA4, Anti-alpha4 integrin, Natalizumab [Chemical/Ingredient] 
A humanized recombinant IgG4 monoclonal antibody directed against the alpha4 subunit of the integrins alpha4beta1and alpha4beta7 with… 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Progressive multifocal leukoencephalopathy (PML) is associated with natalizumab treatment. We quantified the risk of… 
Highly Cited
2006
Highly Cited
2006
BACKGROUND Natalizumab is the first alpha4 integrin antagonist in a new class of selective adhesion-molecule inhibitors. We… 
Highly Cited
2006
Highly Cited
2006
BACKGROUND Interferon beta is used to modify the course of relapsing multiple sclerosis. Despite interferon beta therapy, many… 
Review
2006
Review
2006
BACKGROUND Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with… 
Highly Cited
2005
Highly Cited
2005
BACKGROUND Natalizumab, a humanized monoclonal antibody against alpha4 integrin, inhibits leukocyte adhesion and migration into… 
Highly Cited
2005
Highly Cited
2005
We describe the clinical course of a patient with multiple sclerosis in whom progressive multifocal leukoencephalopathy (PML), an… 
Highly Cited
2005
Highly Cited
2005
A 46-year-old woman with relapsing-remitting multiple sclerosis died from progressive multifocal leukoencephalopathy (PML) after… 
Highly Cited
2005
Highly Cited
2005
The prior diagnosis of fatal astrocytoma in a 60-year-old man with Crohn's disease treated with natalizumab, a monoclonal… 
Highly Cited
2003
Highly Cited
2003
BACKGROUND In patients with multiple sclerosis, inflammatory brain lesions appear to arise from autoimmune responses involving… 
Highly Cited
2003
Highly Cited
2003
BACKGROUND In chronic inflammatory conditions such as Crohn's disease, the migration of leukocytes from the circulation into the…