mts2 endopeptidase protein

Known as: TP15, p15INK4B, CDK4B Inhibitor 
Cyclin-dependent kinase 4 inhibitor B (138 aa, ~15 kDa) is encoded by the human CDKN2B gene. This protein plays a role in the modulation of cell… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory… (More)
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Highly Cited
2011
Highly Cited
2011
A 42 kb region on human chromosome 9p21 encodes for three distinct tumor suppressors, p16INK4A, p14ARF and p15INK4B, and is… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE Recent genome-wide association studies have identified six novel genes for type 2 diabetes and obesity and confirmed… (More)
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Highly Cited
2007
Highly Cited
2007
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge… (More)
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Highly Cited
2007
Highly Cited
2007
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed… (More)
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Highly Cited
2007
Highly Cited
2007
The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association… (More)
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Highly Cited
2001
Highly Cited
2001
Deregulated expression of c-myc can induce cell proliferation in established cell lines and in primary mouse embryonic… (More)
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Highly Cited
1999
Highly Cited
1999
Densely methylated DNA associates with transcriptionally repressive chromatin characterized by the presence of underacetylated… (More)
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Highly Cited
1997
Highly Cited
1997
Four INK4 proteins can prevent cell proliferation by specifically inhibiting cyclin D-dependent kinases. Both p18INK4c and… (More)
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Highly Cited
1995
Highly Cited
1995
Cyclin D-dependent kinases act as mitogen-responsive, rate-limiting controllers of G1 phase progression in mammalian cells. Two… (More)
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