moxifloxacin

Known as: 1-cyclopropyl--7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4as,7as)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid, MOXI 
A fluoroquinolone antibiotic with antibacterial activity. Moxifloxacin binds to and inhibits the bacterial enzymes DNA gyrase (topoisomerase II) and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Early-phase and preclinical studies suggest that moxifloxacin-containing regimens could allow for effective 4-month… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Tuberculosis regimens that are shorter and simpler than the current 6-month daily regimen are needed. METHODS We… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND New drugs, but also shorter, better-tolerated regimens are needed to tackle the high global burden of tuberculosis… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Acute exacerbations contribute to the morbidity and mortality associated with chronic obstructive pulmonary disease… (More)
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Highly Cited
2009
Highly Cited
2009
RATIONALE Moxifloxacin has potent activity against Mycobacterium tuberculosis in vitro and in a mouse model of antituberculosis… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND New treatments are needed to shorten the time required to cure tuberculosis and to treat drug-resistant strains. The… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The long duration of the current tuberculosis (TB) treatment is demanding and warrants the development of new drugs… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Moxifloxacin is a quinolone antimicrobial that has potent activity against Mycobacterium tuberculosis. To optimize… (More)
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Highly Cited
2004
Highly Cited
2004
STUDY OBJECTIVES To compare the effectiveness of oral moxifloxacin with standard antibiotic therapy in acute exacerbation of… (More)
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Highly Cited
1999
Highly Cited
1999
The pharmacokinetics of moxifloxacin and its metabolites M1 (sulpho-compound) and M2 (acyl-glucuronide) were characterized in 12… (More)
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