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By regulating protein degradation, constitutive proteasomes (CPs) control practically all cellular functions. In addition to CPs… Expand Summary BMP-dependent patterning in the Drosophila melanogaster wing imaginal disc serves as a paradigm to understand how… Expand Developmental patterning relies on morphogen concentration gradients, which generally provide invariable positional information… Expand In many instances during development, morphogens specify cell fates by forming concentration gradients. In the Drosophila… Expand Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a… Expand The glypican family of heparan sulfate proteoglycans has been implicated in formation of morphogen gradients. Here, we examine… Expand The role of follistatin as an activin-binding protein has dominated the study of this molecule for the last 10 years. However… Expand Cell pattern in the ventral neural tube is organized by Sonic hedgehog (Shh) secreted by floor plate cells. To assay the range of… Expand Morphogens are secreted proteins that organize surrounding tissues into distinct territories and are thought to act as a function… Expand