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monorden

Known as: Radicicol, monordene, (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-Tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione 
A macrocyclic antifungal antibiotic that inhibits signal-dependent transcriptional activation and induces differentiation in leukemia. (NCI)
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

Antifungal AgentsAntimalarialsEnzyme InhibitorsMacrolides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Hsp90 inhibition with resorcyclic acid lactones (RALs).
Heat shock protein 90 (Hsp90) is an ATP-dependent chaperone which is involved in the post-translational maturation and… 
Highly Cited
2009
Highly Cited
2009
Structural basis of the radicicol resistance displayed by a fungal hsp90.
Heat shock protein 90 (Hsp90) is a promising cancer drug target, as multiple oncogenic proteins are destabilized simultaneously… 
2006
2006
Low Resistance Integrated Toroidal Inductors for Power Management
5.6times5.6times0.5 mm3 integrated toroidal inductors with high L/RDC ratio have been fabricated on Si substrates with… 
2006
2006
Design, synthesis, and structure--activity relationships for chimeric inhibitors of Hsp90.
Inhibition of the 90 kDa heat shock protein (Hsp90) family of molecular chaperones represents a promising new chemotherapeutic… 
2004
2004
Adenosine nucleotides and the regulation of GRP94-client protein interactions.
The molecular chaperone heat shock protein 90 (Hsp90) serves essential roles in the regulation of signaling protein function… 
2001
2001
Role of the Heat Shock Protein 90 in Immune Response Stimulation by Bacterial DNA and Synthetic Oligonucleotides
ABSTRACT To elucidate the mechanisms of immunostimulation by bacterial DNA and synthetic oligonucleotides, the effects of heat… 
2001
2001
Calmodulin tagging provides a general method of using lanthanide induced magnetic field orientation to observe residual dipolar couplings in proteins in solution
A general method is presented for magnetic field alignment of proteins in solution. By tagging a target protein with calmodulin… 
Highly Cited
1995
Highly Cited
1995
Suppression of RAS and MOS transformation by radicicol.
Activated versions of ras and mos oncogenes subvert the signal transduction pathway by mimicking transducers at the plasma… 
Highly Cited
1994
Highly Cited
1994
Calcium-dependent inactivation of light-sensitive channels in Drosophila photoreceptors
Whole-cell voltage clamp recordings were made from photoreceptors of dissociated Drosophila ommatidia under conditions when the… 
Review
1985
Review
1985
Four definitions of endogenous depression and the dexamethasone suppression test.
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