monomethyl auristatin E

Known as: MMAE, Monomethylauristatin E, N(sup 2)-(N-methyl-L-valyl)-N(sup 1)-((1S,2R)-4-((2S)-2-((1R,2R)-3-(((1R,2S)-2-hydroxy-1-methyl-2- phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-2-methoxy-1-((1S)-1-methylpropyl)-4-oxobutyl)-N(sup 1)-methyl-L-valinamide 
A dolastatin-10 peptide derivative with potent antimitotic activity and potential antineoplastic activity as part of an antibody-drug conjugate (ADC… (More)
National Institutes of Health

Papers overview

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2015
2015
Antibody-drug conjugates (ADCs) have demonstrated clinical benefits that have led to the recent FDA approval of KADCYLA and… (More)
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2014
2014
Mesothelin (MSLN) is an attractive target for antibody-drug conjugate therapy because it is highly expressed in various… (More)
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2013
2013
Antibody-drug conjugates (ADC), potent cytotoxic drugs linked to antibodies via chemical linkers, allow specific targeting of… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Hodgkin's lymphoma and anaplastic large-cell lymphoma are the two most common tumors expressing CD30. Previous… (More)
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Highly Cited
2008
Highly Cited
2008
Antibody-drug conjugates enhance the antitumor effects of antibodies and reduce adverse systemic effects of potent cytotoxic… (More)
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Highly Cited
2006
Highly Cited
2006
The chimeric anti-CD30 monoclonal antibody cAC10, linked to the antimitotic agents monomethyl auristatin E (MMAE) or F (MMAF… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Advanced melanoma is a highly drug-refractory neoplasm representing a significant unmet medical need. We sought to… (More)
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Highly Cited
2005
Highly Cited
2005
Effective antibody-drug conjugates (ADC) combine high drug-linker stability in circulation and efficient intratumoral release of… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE An antibody-drug conjugate consisting of monomethyl auristatin E (MMAE) conjugated to the anti-CD30 monoclonal antibody… (More)
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Highly Cited
2003
Highly Cited
2003
The chimeric monoclonal antibody cAC10, directed against CD30, induces growth arrest of CD30+ cell lines in vitro and has… (More)
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