monacolin J

Known as: 2H-Pyran-2-one, 6-(2-(1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl)ethyl)tetrahydro-4-hydroxy- 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2017
0119862017

Papers overview

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2011
2011
Lovastatin, a cyclic nonaketide from Aspergillus terreus, is a hypercholesterolemic agent and a precursor to simvastatin, a semi… (More)
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Highly Cited
2011
Highly Cited
2011
There is growing evidence to support the hypothesis that statins may act as neuroprotectants in several neuropathological… (More)
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2010
2010
A fungal strain able to naturally accumulate large amounts of monacolin J was improved by N-methyl-N′-nitro-N-nitrosoguanidine… (More)
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2009
2009
Monacolin K (MK), which is widely used as an antihypercholesterolemia medicine, is produced as a fungal secondary metabolite… (More)
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2007
2007
Simvastatin is a semisynthetic derivative of the fungal polyketide lovastatin and is an important drug for lowering cholesterol… (More)
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2006
2006
The natural product lovastatin and its semisynthetic, more effective derivative, simvastatin, are important drugs for the… (More)
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2004
2004
Several Monascus and Aspergillus strains were screened for statins production. Lovastatin, monacolin J, pravastatin and… (More)
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1990
1990
tiydroxylation of monacolin L to monacolin J by M. ruberlt8). The present communication deals with the transformation of… (More)
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1989
1989
The microbial metabolites monacolins J and L are specific inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, the rate… (More)
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1986
1986
Monacolin M, a new specific inhibitor of cholesterol biosynthesis structurally related to monacolin K (mevinolin), was isolated… (More)
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