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mofarotene

Known as: (E)-4-[2-[4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]phenoxy]ethyl]morpholine, 4-((2-(p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl)phenoxy)ethyl))morpholine, Mofarontene 
An arotinoic acid derivative with a morpholine structure in the polar end group with differentiation inducing and antineoplastic activity. Like other… Expand
National Institutes of Health

Papers overview

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2004
2004
Tumour cell motility, which is dependent on the organization of the cytoskeleton, is considered to play an important role in the… Expand
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2003
2003
In the search for retinoids active against Burkitt's lymphoma (BL), we found that the arotinoid mofarotene (Ro 40-8757) induced… Expand
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1997
1997
Effective chemotherapy for pancreatic cancer is urgently needed. The anti‐proliferative activity of a new retinoid, mofarotene… Expand
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1996
1996
A sensitive and specific high-performance liquid chromatographic method was developed and validated for the determination of the… Expand
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1996
1996
Contexte - Autant que des agents therapeutiques efficaces, les retinoides sont consideres comme les plus prometeurs des agents… Expand
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1995
1995
Allometric scaling (a technique which uses data obtained in laboratory animals to predict human pharmacokinetics) works well for… Expand
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1995
1995
The chemopreventive effect of dietary administration of a new arotinoid, mofarotene (Ro 40-8757), which contains a morpholine… Expand
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1995
1995
The arotinoid mofarotene is a novel potent anticancer compound. The metabolic profiles obtained from rat, dog, and human plasma… Expand
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1995
1995
The effect of the arotinoid mofarotene (Ro 40-8757; 4-[2-[p-[(E)- 2(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)- propenyl… Expand
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1994
1994
To understand the mechanism of action of the antitumor arotinoid mofarotene (Ro 40‐8757), differential screening of cDNA… Expand
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