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mofarotene

Known as: (E)-4-[2-[4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]phenoxy]ethyl]morpholine, 4-((2-(p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl)phenoxy)ethyl))morpholine, Mofarontene 
An arotinoic acid derivative with a morpholine structure in the polar end group with differentiation inducing and antineoplastic activity. Like other… Expand
National Institutes of Health

Papers overview

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2004
2004
Tumour cell motility, which is dependent on the organization of the cytoskeleton, is considered to play an important role in the… Expand
2003
2003
In the search for retinoids active against Burkitt's lymphoma (BL), we found that the arotinoid mofarotene (Ro 40-8757) induced… Expand
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1997
1997
Effective chemotherapy for pancreatic cancer is urgently needed. The anti‐proliferative activity of a new retinoid, mofarotene… Expand
1996
1996
A sensitive and specific high-performance liquid chromatographic method was developed and validated for the determination of the… Expand
1995
1995
Allometric scaling (a technique which uses data obtained in laboratory animals to predict human pharmacokinetics) works well for… Expand
1995
1995
The arotinoid mofarotene is a novel potent anticancer compound. The metabolic profiles obtained from rat, dog, and human plasma… Expand
1995
1995
The chemopreventive effect of dietary administration of a new arotinoid, mofarotene (Ro 40-8757), which contains a morpholine… Expand
1995
1995
The effect of the arotinoid mofarotene (Ro 40-8757; 4-[2-[p-[(E)- 2(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)- propenyl… Expand
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1994
1994
To understand the mechanism of action of the antitumor arotinoid mofarotene (Ro 40‐8757), differential screening of cDNA… Expand
1994
1994
Combination therapy with 5‐Fluorouracil (5‐FU) and the arotinoid Ro 40‐8757 (mofarotene) of established chemically induced… Expand